Interleukin-12 and tumor necrosis factor-alpha levels in cerebrospinal fluid of multiple sclerosis patients

被引：46

作者：

Drulovic, J ^{[1
]}

MostaricaStojkovic, M ^{[1
]}

Levic, Z ^{[1
]}

Stojsavljevic, N ^{[1
]}

Pravica, V ^{[1
]}

Mesaros, S ^{[1
]}

机构：

[1] UNIV BELGRADE, SCH MED, INST MICROBIOL & IMMUNOL, YU-11000 BELGRADE, YUGOSLAVIA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 147卷 / 02期

关键词：

interleukin-12; tumor necrosis factor-alpha; multiple sclerosis; cerebrospinal fluid;

D O I：

10.1016/S0022-510X(96)05320-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Concentrations of interleukin (IL)-12 and tumor necrosis factor-alpha (TNF-alpha) in cerebrospinal fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent assay. TNF-alpha was detectable in the CSF of 60% of the patients with active MS, none of those with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-alpha correlated with the degree of disability in MS patients (P<0.05). Detectable levels of IL-12 were found in 10% of the MS CSF samples and 18% of NIND CSF samples. There was a significant relationship between CSF concentrations of IL-12 and those of TNF-alpha in MS patients (P<0.05); no relationship was observed between the presence of IL-12 and disease activity or severity. These findings further stress the involvement of T helper 1 type-response within the central nervous system in MS. (C) 1997 Elsevier Science BV.

引用

页码：145 / 150

页数：6

共 42 条

[1] COOPERATION OF NATURAL-KILLER-CELL STIMULATORY FACTOR INTERLEUKIN-12 WITH OTHER STIMULI IN THE INDUCTION OF CYTOKINES AND CYTOTOXIC CELL-ASSOCIATED MOLECULES IN HUMAN T-CELLS AND NK-CELLS [J].