Effect of dexmedetomidine on erythrocyte deformability during ischemia-reperfusion injury of liver in diabetic rats

被引:13
作者
Arslan, M. [1 ]
Comu, F. M. [2 ]
Isik, B. [1 ]
Ozturk, L. [3 ]
Kesimci, E. [3 ]
机构
[1] Gazi Univ, Fac Med, Dept Anaesthesiol & Reanimat, TR-06510 Ankara, Turkey
[2] Kirikkale Univ, Fac Med, Dept Physiol, Kirikkale, Turkey
[3] Ankara Ataturk Training & Res Hosp, Dept Anaesthesiol & Reanimat, Ankara, Turkey
来源
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2012年 / 113卷 / 12期
关键词
erythrocyte deformability; ischemia reperfusion; alpha(2) agonist; experimental diabetes; dexmedetomidine; rat; NITRIC-OXIDE; ISCHEMIA/REPERFUSION; ANESTHESIA; EXPRESSION; APOPTOSIS; SEDATION;
D O I
10.4149/BLL_2012_156
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: The aim of this study is to evaluate the effect of dexmedetomidine on erythrocyte deformability during IR injury of liver in diabetic rats. Methods: Twenty-eight Wistar Albino rats were included in the study after a 4 week streptozocin (65 mg/kg) treatment to observe the existence of diabetes. The animals were randomly assigned to one of the four experimental groups: GroupC and DC (sham-control group): The abdomen was dissected with a median laparotomy and the liver was collected. GroupDIR: The liver was collected after IR following the abdominal median laparotomy. GroupDIRD: The liver was collected after IR following the abdominal median laparotomy and 30 min of infusion of dexmedetomidine 100 mu g/kg ip The deformability measurements were performed in erythrocyte suspensions containing Htc 5% in PBS buffer. Results: The deformability index was significantly increased in diabetic rats, however it was similar in the GroupC and DIRD. It was significantly increased in the GroupDIR when compared to the GroupC, DIRD and DC. The relative resistance was increased in IR models. Conclusion: Erythrocyte deformability was damaged in rats having diabetes and IR injury. This injury might lead to further problems in microcirculation. It was shown that dexmedetomidine may be useful in enhancing the adverse effects of this injury (Tab. 1, Fig. 2, Ref. 41). Full Text in PDF www.elis.sk.
引用
收藏
页码:687 / 691
页数:5
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