Pneumocystis jirovecii pneumonia prophylaxis during temozolomide treatment for high-grade gliomas

被引：23
作者：
De Vos, Filip Y. [1 ]
Gijtenbeek, Johanna M. [2 ]
Bleeker-Rovers, Chantal P. [3 ]
van Herpen, Carla M. [4 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3508 GA Utrecht, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Neurooncol, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med Infect Dis, NL-6500 HB Nijmegen, Netherlands
[4] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6500 HB Nijmegen, Netherlands
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2013年 / 85卷 / 03期
关键词：
Pneumocystis jirovecii; Prophylaxis; Temozolomide; High-grade glioma; DOSE-DENSE TEMOZOLOMIDE; HIV-INFECTED PATIENTS; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; CARINII-PNEUMONIA; AEROSOLIZED PENTAMIDINE; TRIMETHOPRIM-SULFAMETHOXAZOLE; DAPSONE-PYRIMETHAMINE; RANDOMIZED-TRIAL; IMMUNOCOMPROMISED PATIENTS;
D O I：
10.1016/j.critrevonc.2012.08.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-grade glioma patients receiving concomitant chemoradiotherapy with temozolomide 75 mg/m(2) during six to seven weeks or dose-dense temozolomide regimens especially in combination with chronic use of corticosteroids have a high risk for developing Pneumocystis jirovecii pneumonia. In this review, we define risk groups and propose a guideline for prophylaxis using risk stratification. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：373 / 382
页数：10
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