High Expression of FoxP1 Is Associated With Improved Survival in Patients With Non-Small Cell Lung Cancer

被引：65

作者：

Feng, Jian ^{[1
]}

Zhang, Xuesong ^{[1
]}

Zhu, Huijun ^{[2
]}

Wang, Xudong ^{[3
]}

Ni, Songshi ^{[1
]}

Huang, Jianfei ^{[2
]}

机构：

[1] Nantong Univ, Dept Resp Med, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

[2] Nantong Univ, Dept Pathol, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

[3] Nantong Univ, Dept Lab Med, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2012年 / 138卷 / 02期

关键词：

FoxP1; Non-small cell lung cancer; Tissue microarray; Immunohistochemistry; Prognosis; FORKHEAD TRANSCRIPTION FACTOR; ANDROGEN RECEPTOR; PROSTATE-CANCER; LYMPHOMA; TARGET; GENE;

D O I：

10.1309/AJCPDHQFNYJZ01YG

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

FoxP1 has been reported to be expressed in several types of human malignant tumors, and has been associated with metastasis and patient prognosis. Quantitative real-time polymerase chain reaction (PCR) and immunohistochemical analysis with tissue microarray were used to characterize the expression of FoxP1 in non-small cell lung cancer (NSCLC). It was revealed that the expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NSCLC tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively). The expression of FoxP1 protein in NSCLC was related to gender, histologic type, and 5-year survival rate (all P < .05). Finally, we evaluated the prognostic significance of the expression of FoxP1 in a group of patients. Kaplan-Meier survival and Cox regression analyses showed that low expression of FoxP1 (P < .001) and later stage grouping by TNM (P = .022) were independent factors predicting poor prognosis for NSCLC.

引用

页码：230 / 235

页数：6

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