Baseline renal insufficiency and risk of death among HIV-infected adults on antiretroviral therapy in Lusaka, Zambia

被引：85

作者：

Mulenga, Lloyd B. ^{[1
]}

Kruse, Gina ^{[1
]}

Lakhi, Shabir ^{[2
]}

Cantrell, Ronald A. ^{[1
,3
,4
]}

Reid, Stewart E. ^{[1
,3
,4
]}

Zulu, Isaac ^{[5
,6
]}

Stringer, Elizabeth M. ^{[1
,3
,4
]}

Krishnasami, Zipporah ^{[3
,4
]}

Mwinga, Alwyn ^{[5
]}

Saag, Michael S. ^{[3
,4
]}

Stringer, Jeffrey S. A. ^{[1
,3
,4
]}

Chi, Benjamin H. ^{[1
,3
,4
]}

机构：

[1] Ctr Infect Dis Res, Lusaka, Zambia

[2] Univ Teaching Hosp, Lusaka, Zambia

[3] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA

[4] Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA

[5] US Ctr Dis Control & Prevent Global AIDS Program, Lusaka, Zambia

[6] Univ Zambia, Sch Med, Lusaka, Zambia

来源：

AIDS | 2008年 / 22卷 / 14期

基金：

美国国家卫生研究院;

关键词：

antiretroviral therapy; HIV; mortality; renal disease; sub-Saharan Africa; survival; Zambia;

D O I：

10.1097/QAD.0b013e328307a051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: To examine the association between baseline renal insufficiency and mortality among adults initiating antiretroviral therapy (ART) in an urban African setting. Design: Open cohort evaluation. Methods: We examined mortality according to baseline renal function among adults initiating ART in Lusaka, Zambia. Renal function was assessed by the Cockcroft-Gault method, the Modification of Diet in Renal Disease equation, and serum creatinine. Results: From April 2004 to September 2007, 25 779 individuals started ART with an available creatinine measurement at baseline. When creatinine clearance was calculated by the Cockcroft-Gault method, 8456 (33.5%) had renal insufficiency: 73.5% were mild (60-89 ml/min), 23.4% moderate (30-59 ml/min), and 3.1% severe (<30 ml/min). Risk for mortality at or before 90 days was elevated for those with mildly [adjusted hazard ratio (AHR) 1.7; 95% confidence interval (951% CI) = 1.5-1.9], moderately (AHR = 2.3; 95% CI 2.0-2.7), an

引用

页码：1821 / 1827

页数：7

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