Synthesis of 4-arylethyl-6-arylpyrimidine-2-thiols through aza-Michael addition/nucleophilic addition/aromatization tandem reactions

被引：4

作者：

Li, Zheng ^{[1
]}

Song, Wenli ^{[1
]}

He, Jiaojiao ^{[1
]}

Du, Yan ^{[1
]}

Yang, Jingya ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

来源：

HETEROCYCLIC COMMUNICATIONS | 2018年 / 24卷 / 01期

基金：

中国国家自然科学基金;

关键词：

4-arylethyl-6-arylpyrimidine-2-thiol; divinyl ketone; tandem reaction; thiourea; SPECTROPHOTOMETRIC DETERMINATION; PYRIMIDINE-2-THIOL; EXTRACTION; COMPLEXES; DERIVATIVES; SEPARATION; THIOUREA; LIGAND;

D O I：

10.1515/hc-2017-0169

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of the title compounds by reactions of divinyl ketones with thiourea is described. This protocol has the advantages of high yields, mild reaction conditions and simple work-up procedure.

引用

页码：23 / 26

页数：4

共 22 条

[1] Re2(CO)6(μ-thpymS)2 (thpymSH = pyrimidine-2-thiol) as a versatile precursor to mono- and polynuclear complexes: X-ray crystal structures of fac-Re(CO)3(PPh3)(κ2-thpymS) and two isomers of ReRu3(CO)13(μ3-thpymS) [J].

Ahmad, Md. Faruque ;

Sarker, Jagodish C. ;

Azam, Kazi A. ;

Kabir, Shariff E. ;

Ghosh, Shishir ;

Hogarth, Graeme ;

Siddiquee, Tasneem A. ;

Richmond, Michael G. .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2013, 728 :30-37

[2]

Bansal V, 2008, INDIAN J PHARMACOL, V40, P117

[3]

CROSBY DG, 1963, ORG SYNTH, V43, P68

[4] Electrochemical Oxidation of Catechols in the Presence of Pyrimidine-2-thiol: Application to Electrosynthesis [J].

Fotouhi, Lida ;

Behrozi, Ladan ;

Heravi, Majid M. ;

Nematollahi, Davood .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (10) :2749-2757

[5]

Ghaedi M, 2006, CHEM ANAL-WARSAW, V51, P593

[6] Highly Selective Claisen-Schmidt Condensation Catalyzed by Silica Chloride Under Solvent-Free Reaction Conditions [J].

Hazarkhani, Hassan ;

Kumar, Pradeep ;

Kondiram, Kadam Sachin ;

Gadwal, Ikhlas M. Shafi .

SYNTHETIC COMMUNICATIONS, 2010, 40 (19) :2887-2896

[7] Synthesis, antitubercular evaluation and 3D-QSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivatives [J].

Khunt, R. C. ;

Khedkar, V. M. ;

Chawda, R. S. ;

Chauhan, N. A. ;

Parikh, A. R. ;

Coutinho, E. C. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) :666-678

[8]

Kolekar GB, 1998, ANAL LETT, V31, P2241

[9] THE ANION OF PYRIMIDINE-2-THIOL AS A LIGAND TO MOLYBDENUM, TUNGSTEN, AND IRON - PREPARATION OF COMPLEXES, THEIR STRUCTURE AND REACTIVITY [J].

LATHAM, IA ;

LEIGH, GJ ;

PICKETT, CJ ;

HUTTNER, G ;

JIBRILL, I ;

ZUBIETA, J .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1986, (06) :1181-1187

[10] Extraction of ruthenium(IV) from hydrochloric acid medium with N-octylaniline and its determination spectrophotometrically with pyrimidine-2-thiol [J].

Lokhande, T ;

Kolekar, GB ;

Anuse, MA ;

Chavan, MB .

SEPARATION SCIENCE AND TECHNOLOGY, 2000, 35 (01) :153-168

← 1 2 3 →