共 32 条
XRCC3 and RAD51 Expression Are Associated with Clinical Factors in Breast Cancer
被引:27
作者:

Hu, Jia
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Oncol 2, Beijing, Peoples R China
Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Oncol 2, Beijing, Peoples R China

Wang, Ning
论文数: 0 引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Oncol 2, Beijing, Peoples R China

Wang, Ya-Jie
论文数: 0 引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Oncol 2, Beijing, Peoples R China
机构:
[1] Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Oncol 2, Beijing, Peoples R China
[2] Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai, Peoples R China
来源:
关键词:
IONIZING-RADIATION;
REPAIR;
RECEPTOR;
CELLS;
CARCINOMA;
SURVIVAL;
GENE;
EGFR;
PROGESTERONE;
METAANALYSIS;
D O I:
10.1371/journal.pone.0072104
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Aims: XRCC3 and RAD51 are two important members in homologous recombination repair pathway. This study was performed to detect the expressions of these two molecules in breast cancer and explore their correlations with clinicopathological factors. Methods and Results: Immunohistochemistry was used to detect protein expressions of XRCC3 and RAD51 in 248 cases of breast cancer tissue and 78 cases of adjacent non-cancerous tissue. Data showed that expressions for both XRCC3 and RAD51 were significantly increased in breast cancer. High XRCC3 expression was associated with large tumor size and positive PR and HER2 status, while high RAD51 expression was associated with axillary lymph node metastasis and positive PR and HER2 status. The result of multivariate analysis demonstrated that HER2, PR and RAD51 were significantly association with XRCC3. And besides XRCC3, axillary lymph node metastasis and PR were significantly correlated with RAD51. Conclusions: XRCC3 and RAD51 were significantly associated with clinicopathological factors and they might play important roles in the development and progress of breast cancer.
引用
收藏
页数:6
相关论文
共 32 条
[21]
The Effect of a DNA Repair Gene on Cellular Invasiveness: Xrcc3 Over-Expression in Breast Cancer Cells
[J].
Martinez-Marignac, Veronica L.
;
Rodrigue, Amelie
;
Davidson, David
;
Couillard, Martin
;
Al-Moustafa, Ala-Eddin
;
Abramovitz, Mark
;
Foulkes, William D.
;
Masson, Jean-Yves
;
Aloyz, Raquel
.
PLOS ONE,
2011, 6 (01)

Martinez-Marignac, Veronica L.
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Rodrigue, Amelie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Genome Stabil Lab, Canc Res Ctr, Hotel Dieu Quebec, Quebec City, PQ, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Davidson, David
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Couillard, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Al-Moustafa, Ala-Eddin
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Abramovitz, Mark
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Foulkes, William D.
论文数: 0 引用数: 0
h-index: 0
机构:
McGill Univ, Fac Med, Program Canc Genet, Montreal, PQ H3T 1E2, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

Masson, Jean-Yves
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Genome Stabil Lab, Canc Res Ctr, Hotel Dieu Quebec, Quebec City, PQ, Canada McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

论文数: 引用数:
h-index:
机构:
[22]
Breast cancer outcomes by steroid hormone receptor status assessed visually and by computer image analysis
[J].
Mohammed, Zahra M. A.
;
Edwards, Joanne
;
Orange, Clare
;
Mallon, Elizabeth
;
Doughty, Julie C.
;
McMillan, Donald C.
;
Going, James J.
.
HISTOPATHOLOGY,
2012, 61 (02)
:283-292

Mohammed, Zahra M. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland
Univ Glasgow, Western Infirm, Univ Dept Pathol, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland

Edwards, Joanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Inst Canc, Coll Med Vet & Life Sci, Unit Expt Therapeut, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland

Orange, Clare
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Western Infirm, Univ Dept Pathol, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland

Mallon, Elizabeth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Western Infirm, Univ Dept Pathol, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland

Doughty, Julie C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Western Infirm, Dept Surg, Glasgow G11 6NT, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland

McMillan, Donald C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland

Going, James J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Inst Canc, Coll Med Vet & Life Sci, Unit Expt Therapeut, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow, Royal Infirm, Coll Med Vet & Life Sci, Acad Surg Unit, Glasgow G31 2ER, Lanark, Scotland
[23]
Perturbation of sheep ovarian surface epithelial cells by ovulation: evidence for roles of progesterone and poly(ADP-ribose) polymerase in the restoration of DNA integrity
[J].
Murdoch, WJ
.
JOURNAL OF ENDOCRINOLOGY,
1998, 156 (03)
:503-508

Murdoch, WJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wyoming, Reprod Biol Program, Laramie, WY 82071 USA Univ Wyoming, Reprod Biol Program, Laramie, WY 82071 USA
[24]
In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status
[J].
Myllynen, Laura
;
Rieckmann, Thorsten
;
Dahm-Daphi, Jochen
;
Kasten-Pisula, Ulla
;
Petersen, Cordula
;
Dikomey, Ekkehard
;
Kriegs, Matte
.
RADIOTHERAPY AND ONCOLOGY,
2011, 101 (01)
:147-151

Myllynen, Laura
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany

Rieckmann, Thorsten
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany

Dahm-Daphi, Jochen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Marburg, Inst Radiobiol & Mol Radiat Oncol, D-35032 Marburg, Germany Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany

Kasten-Pisula, Ulla
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany

Petersen, Cordula
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Hamburg Eppendorf, Dept Radiotherapy & Radiooncol, D-20246 Hamburg, Germany Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany

Dikomey, Ekkehard
论文数: 0 引用数: 0
h-index: 0
机构: Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany

Kriegs, Matte
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany Univ Med Ctr Hamburg Eppendorf, Lab Radiobiol & Expt Radiooncol, Univ Canc Ctr Hamburg, D-20246 Hamburg, Germany
[25]
XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis
[J].
Qiu, Li-Xin
;
Mao, Chen
;
Yao, Lei
;
Yu, Ke-Da
;
Zhan, Ping
;
Chen, Bo
;
Liu, Hai-Guang
;
Yuan, Hui
;
Zhang, Jian
;
Xue, Kai
;
Hu, Xi-Chun
.
BREAST CANCER RESEARCH AND TREATMENT,
2010, 122 (02)
:489-493

Qiu, Li-Xin
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Mao, Chen
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Yao, Lei
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Yu, Ke-Da
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China
Fudan Univ, Canc Hosp, Dept Breast Surg, Breast Canc Inst, Shanghai 200433, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Zhan, Ping
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Chest Hosp, Dept Resp Med, Nanjing, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Chen, Bo
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Liu, Hai-Guang
论文数: 0 引用数: 0
h-index: 0
机构:
Wenzhou Med Coll, Affiliated Hosp 1, Dept Oncol, Wenzhou, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Yuan, Hui
论文数: 0 引用数: 0
h-index: 0
机构: Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Zhang, Jian
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Xue, Kai
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China

Hu, Xi-Chun
论文数: 0 引用数: 0
h-index: 0
机构:
Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China Fudan Univ, Canc Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China
[26]
Links between DNA double strand break repair and breast cancer:: Accumulating evidence from both familial and nonfamilial cases
[J].
Ralhan, Ranju
;
Kaur, Jatinder
;
Kreienberg, Rolf
;
Wiesmueller, Lisa
.
CANCER LETTERS,
2007, 248 (01)
:1-17

Ralhan, Ranju
论文数: 0 引用数: 0
h-index: 0
机构: All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

Kaur, Jatinder
论文数: 0 引用数: 0
h-index: 0
机构: All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

Kreienberg, Rolf
论文数: 0 引用数: 0
h-index: 0
机构: All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

Wiesmueller, Lisa
论文数: 0 引用数: 0
h-index: 0
机构: All India Inst Med Sci, Dept Biochem, New Delhi 110029, India
[27]
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability
[J].
Richardson, C
;
Stark, JM
;
Ommundsen, M
;
Jasin, M
.
ONCOGENE,
2004, 23 (02)
:546-553

Richardson, C
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ Coll Phys & Surg, Inst Canc Genet, Dept Pathol, New York, NY 10032 USA

Stark, JM
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ Coll Phys & Surg, Inst Canc Genet, Dept Pathol, New York, NY 10032 USA

Ommundsen, M
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ Coll Phys & Surg, Inst Canc Genet, Dept Pathol, New York, NY 10032 USA

Jasin, M
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ Coll Phys & Surg, Inst Canc Genet, Dept Pathol, New York, NY 10032 USA
[28]
ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway
[J].
Toulany, Mamoud
;
Minjgee, Minjmaa
;
Kehlbach, Rainer
;
Chen, Jianyong
;
Baumann, Michael
;
Rodemann, H. Peter
.
RADIOTHERAPY AND ONCOLOGY,
2010, 97 (02)
:338-345

Toulany, Mamoud
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany

Minjgee, Minjmaa
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany

Kehlbach, Rainer
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Diagnost & Intervent Radiol, D-72076 Tubingen, Germany Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany

Chen, Jianyong
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany

Baumann, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dresden, Dept Radiat Oncol, Dresden, Germany Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany

Rodemann, H. Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany Univ Tubingen, Dept Radiat Oncol, Div Radiobiol & Mol Environm Res, D-72076 Tubingen, Germany
[29]
Ten genes for inherited breast cancer
[J].
Walsh, Tom
;
King, Mary-Claire
.
CANCER CELL,
2007, 11 (02)
:103-105

Walsh, Tom
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Dept Med, Seattle, WA 98195 USA

King, Mary-Claire
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Med, Seattle, WA 98195 USA
[30]
In vitro evidence for homologous recombinational repair in resistance to melphalan
[J].
Wang, ZM
;
Chen, ZP
;
Xu, ZY
;
Christodoulopoulos, G
;
Bello, V
;
Mohr, G
;
Aloyz, R
;
Panasci, LC
.
JOURNAL OF THE NATIONAL CANCER INSTITUTE,
2001, 93 (19)
:1473-1478

Wang, ZM
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Chen, ZP
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Xu, ZY
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Christodoulopoulos, G
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Bello, V
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Mohr, G
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Aloyz, R
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

Panasci, LC
论文数: 0 引用数: 0
h-index: 0
机构: McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada