The relationship between exposed galactose and N-acetylglucosamine residues on IgG in rheumatoid arthritis (RA), juvenile chronic arthritis (JCA) and Sjogren's syndrome (SS)

被引：57

作者：

Bond, A ^{[1
]}

Alavi, A ^{[1
]}

Axford, JS ^{[1
]}

Youinou, P ^{[1
]}

Hay, FC ^{[1
]}

机构：

[1] CTR HOSP REG & UNIV BREST, IMMUNOL LAB, BREST, BELARUS

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1996年 / 105卷 / 01期

关键词：

immunoglobulin G; glycosylation; Sjogren's syndrome; rheumatoid arthritis;

D O I：

10.1046/j.1365-2249.1996.d01-741.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relationship between exposed galactose and N-acetylglucosamine on IgG in RA, JCA and SS was investigated. This was achieved using IgG isolated from serum where the levels of galactose and N-acetylglucosamine (GlcNAc) were detected using biotinylated lectins. Galactose and GlcNAc on IgG from patients with RA and JCA, are inversely related, but in contrast, in SS, galactose expression on IgG decreased while GlcNAc expression remained similar to normal levels. Alterations in IgG glycosylation are closely associated with the development of adult and juvenile chronic arthritis and SS, but the changes involved are different in RA compared with SS, suggesting that the precise pattern of exposed sugars is associated with different rheumatological diseases.

引用

页码：99 / 103

页数：5

共 21 条

[1] EVALUATION OF BETA-1,4-GALACTOSYLTRANSFERASE IN RHEUMATOID-ARTHRITIS AND ITS ROLE IN THE GLYCOSYLATION NETWORK ASSOCIATED WITH THIS DISEASE [J].