Near-Infrared Light-Mediated Nanoplatforms for Cancer Thermo-Chemotherapy and Optical Imaging

被引:598
作者
Zhang, Zhenjiang [1 ]
Wang, Jing [1 ]
Chen, Chunying [1 ]
机构
[1] Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
基金
对外科技合作项目(国际科技项目); 美国国家科学基金会;
关键词
photothermal nanoparticles; thermo-chemotherapy; optical imaging; controlled drug delivery; cancer treatments;
D O I
10.1002/adma.201301890
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
While thermo-chemotherapy has proved to be effective in optimizing the efficacies of cancer treatments, traditional chemotherapy is subject to adverse side effects and heat delivery is often challenging in operation. Some photothermal inorganic nanoparticles responsive to near infrared light provide new opportunities for simultaneous and targeted delivery of heat and chemotherapeutics to the tumor sites in pursuit of synergistic effects for efficacy enhancement. The state of the art of nanoparticle-induced thermo-chemotherapy is summarized and the advantages and challenges of the major nanoplatforms based on gold nanoparticles, carbon nanomaterials, palladium nanosheets, and copper-based nanocrystals are highlighted. In addition, the optical-imaging potentials of the nanoplatforms that may endow them with imaging-guided therapy and therapeutic-result-monitoring capabilities are also briefly discussed.
引用
收藏
页码:3869 / 3880
页数:12
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