Interaction with the Yes-associated protein (YAP) allows TEAD1 to positively regulate NAIP expression

被引:11
作者
Malt, Andre Landin [1 ]
Georges, Adrien [2 ]
Silber, Joel [1 ]
Zider, Alain [1 ,2 ]
Flagiello, Domenico [1 ]
机构
[1] Univ Paris Diderot, Sorbonne Paris Cite, Equipe Genet Mol Differenciat, IJM,UMR 7592,CNRS, F-75205 Paris 13, France
[2] Univ Paris Diderot, Sorbonne Paris Cite, Equipe Oncol Mol & Pathol, IJM,UMR 7592,CNRS, F-75205 Paris 13, France
关键词
TEAD1; NAIP; YAP; Hippo pathway; APOPTOSIS-INHIBITORY PROTEIN; DNA-BINDING DOMAIN; TRANSCRIPTION FACTORS; CELL-PROLIFERATION; WING FORMATION; GROWTH-CONTROL; ORGAN SIZE; DROSOPHILA; GENE; PATHWAY;
D O I
10.1016/j.febslet.2013.08.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although the expression of the neuronal apoptosis inhibitory protein (NAIP) gene is considered involved in apoptosis suppression as well as in inflammatory response, the molecular basis of the NAIP gene expression is poorly understood. Here we show that the TEA domain protein 1 (TEAD1) is able to positively activate the transcription of NAIP. We further demonstrate that this regulation is mediated by the presence of the endogenous Yes associated protein (YAP) cofactor, and requires the interaction with YAP. We finally identified an intronic region of the NAIP gene responding to TEAD1/YAP activity, suggesting that regulation of NAIP by TEAD1/YAP is at the transcriptional level. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码:3216 / 3223
页数:8
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