Interest of CSF β-amyloid1-42 and t-tau protein level determinations for the diagnosis of Alzheimer's disease

Early diagnosis of Alzheimer's disease remains a tactful poser. In order to clarify the importance of P amyloid protein dosage (A beta 1-42) and protein tau (t-tau) in Such pathology, we have rigorously studied three well recruited populations that match in age: healthy controls (n = 32), Alzheimer patients (n = 87) and non Alzheimer dementia (n = 31) patients. The combination of A beta 1-42 and t-tau at baseline yielded a sensitivity of 85.29 % for detection of Alzheimer's disease and the specificity was by 96.77 % to differentiate controls. So the combination of these tow markers helps in the diagnosis of Alzheimer because of the high specificity and sensibility of this method.