ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis

被引：29

作者：

Caltabiano, Rosario ^{[1
]}

Puzzo, Lidia ^{[1
]}

Barresi, Valeria ^{[2
]}

Ieni, Antonio ^{[2
]}

Loreto, Carla ^{[3
]}

Musumeci, Giuseppe ^{[3
]}

Castrogiovanni, Paola ^{[3
]}

Ragusa, Marco ^{[4
]}

Foti, Pietro ^{[5
]}

Russo, Andrea ^{[6
]}

Longo, Antonio ^{[6
]}

Reibaldi, Michele ^{[6
]}

机构：

[1] Univ Catania, Sect Anat Pathol, Dept GF Ingrassia, Santa Sofia 87 St, I-95123 Catania, Italy

[2] Univ Messina, Sect Pathol Anat, Dept Human Pathol, I-98100 Messina, Italy

[3] Univ Catania, Div Anat & Histol, Dept Biomed Sci, I-95124 Catania, Italy

[4] Univ Catania, Sect Mol Biomed, Dept Biomed Sci, I-95124 Catania, Italy

[5] Univ Hosp Policlin Vittorio Emanuele, Radiodiagnost & Radiotherapy Unit, Catania, Italy

[6] Univ Catania, Dept Ophthalmol, Catania, Italy

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2016年 / 212卷 / 11期

关键词：

ADAM; 10; Uveal melanoma; Prognosis; Metastasis; Immunohistochemistry; CLEAVAGE; GROWTH;

D O I：

10.1016/j.prp.2016.08.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Uveal melanoma is the most frequent primary intraocular neoplasm in adults. Although malignant melanoma may be located at any point in the uveal tract, the choroid and ciliary body are more frequent locations than the iris. In the present study, we examined ADAM10 expression levels in primary uveal melanoma both with and without metastasis, and we evaluated their association with other high risk characteristics for metastasis in order to assess if ADAM10 can be used to predict metastasis. This study included a total of 52 patients, 23 men and 29 women, with uveal melanoma. A significantly high expression of ADAM-10 was seen in patients with metastasis (11/13, 84.6%), but not in patients without metastasis (15/39, 38.5%). In conclusion we found that ADAM10 expression was associated with a more rapid metastatic progression confirming its role in uveal melanoma metastasis. (C) 2016 Elsevier GmbH. All rights reserved.

引用

页码：980 / 987

页数：8

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