RNA specific molecules: Cytotoxic plant alkaloid palmatine binds strongly to poly(A)

被引：45

作者：

Giri, P ^{[1
]}

Hossain, M ^{[1
]}

Kumar, GS ^{[1
]}

机构：

[1] Indian Inst Chem Biol, Biophys Chem Lab, Kolkata 700032, W Bengal, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 09期

关键词：

palmatine; RNA; poly(A); binding; spectroscopy; ITC;

D O I：

10.1016/j.bmcl.2006.01.124

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (K-a) of (8.36 +/- 0.26) x 10(5) M-1. The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A) has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2364 / 2368

页数：5

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