Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE

被引：53
|
作者：
Zuo, Lihua [1 ]
Meng, Heng [2 ]
Wu, Jingjing [1 ]
Jiang, Zhen [1 ]
Xu, Shuying [1 ]
Guo, Xingjie [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Shenyang 110016, Liaoning Provin, Peoples R China
[2] China Resources Double Crane Pharmaceut Co Ltd, Res Inst, Beijing, Peoples R China
来源：
JOURNAL OF SEPARATION SCIENCE | 2013年 / 36卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Capillary electrophoresis; beta-CD; Enantiomeric purity; Enantioseparation; Ionic liquid; CAPILLARY ELECTROMIGRATION TECHNIQUES; CHIRAL SEPARATION; ELECTROPHORESIS; CYCLODEXTRIN; ACID; ADDITIVES;
D O I：
10.1002/jssc.201200824
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, promethazine hydrochloride, liarozole, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using beta-CD in combination with a chiral ionic liquid (IL), 1-ethyl-3-methylimidazolium-L-lactate. The influence of the type of IL and its concentration, BGE pH, and chain length of the IL cations on the resolution are discussed. Finally, the proposed method was successfully applied for the chiral impurity determination of eszopiclone in pharmaceutical tablets after validation with respect to accuracy and precision, linearity range, selectivity, repeatability, LOD and LOQ. It is assessed that the chiral impurity determination in the commercial tables is fewer than 0.1%.
引用
收藏
页码：517 / 523
页数：7
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