Prostate cancer is the most common cancer in US men and the second leading cause of cancer deaths. Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D. We now show that FGF23 is expressed as an autocrine growth factor in all prostate cancer cell lines tested and is present at increased levels in prostate cancer tissues. Exogenous FGF23 enhances proliferation, invasion and anchorage independent growth in vitro while FGF23 knockdown in prostate cancer cell lines decreases these phenotypes. FGF23 knockdown also decreases tumor growth in vivo. Given that classical FGFs and FGF19 are also increased in prostate cancer, we analyzed expression microarrays hybridized with RNAs from of LNCaP cells stimulated with FGF2, FGF19 or FGF23. The different FGF ligands induce overlapping as well as unique patterns of gene expression changes and thus are not redundant. We identified multiple genes whose expression is altered by FGF23 that are associated with prostate cancer initiation and progression. Thus FGF23 can potentially also act as an autocrine, paracrine and/or endocrine growth factor in prostate cancer that can promote prostate cancer progression.
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Chung, S.
;
Furihata, M.
论文数: 0引用数: 0
h-index: 0
机构:
Kochi Med Sch, Dept Pathol, Nankoku, Kochi, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Furihata, M.
;
Tamura, K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan
Kochi Med Sch, Dept Urol, Nankoku, Kochi, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Tamura, K.
;
Uemura, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Uemura, M.
;
Daigo, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Daigo, Y.
;
Nasu, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Sch Med, Dept Urol, Okayama 700, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Nasu, Y.
;
Miki, T.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Urol, Kyoto, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Miki, T.
;
Shuin, T.
论文数: 0引用数: 0
h-index: 0
机构:
Kochi Med Sch, Dept Urol, Nankoku, Kochi, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Shuin, T.
;
Fujioka, T.
论文数: 0引用数: 0
h-index: 0
机构:
Iwate Med Univ, Dept Urol, Morioka, Iwate 020, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Fujioka, T.
;
Nakamura, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Nakamura, Y.
;
Nakagawa, H.
论文数: 0引用数: 0
h-index: 0
机构:
RIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Creighton, Chad J.
;
Casa, Angelo
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Casa, Angelo
;
Lazard, ZaWaunyka
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Lazard, ZaWaunyka
;
Huang, Shixia
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Huang, Shixia
;
Tsimelzon, Anna
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Tsimelzon, Anna
;
Hilsenbeck, Susan G.
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Hilsenbeck, Susan G.
;
Osborne, Charles Kent
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Osborne, Charles Kent
;
Lee, Adrian V.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USABaylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
机构:
Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Ho, Lye Lin
;
Kench, James G.
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, Australia
Westmead Hosp, Inst Clin Pathol & Med Res, Dept Tissue Pathol, Westmead, NSW 2145, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Kench, James G.
;
Handelsman, David J.
论文数: 0引用数: 0
h-index: 0
机构:
Concord Hosp, ANZAC Res Inst, Sydney, NSW, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Handelsman, David J.
;
Scheffer, George L.
论文数: 0引用数: 0
h-index: 0
机构:
Free Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, NetherlandsSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Scheffer, George L.
;
Stricker, Phillip D.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Urol, Sydney, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Stricker, Phillip D.
;
Grygiel, John G.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hospit, Dept Med Oncol, Sydney, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Grygiel, John G.
;
Sutherland, Robert L.
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Sutherland, Robert L.
;
Henshall, Susan M.
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Henshall, Susan M.
;
Allen, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Allen, John D.
;
Horvath, Lisa G.
论文数: 0引用数: 0
h-index: 0
机构:
Sydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Chung, S.
;
Furihata, M.
论文数: 0引用数: 0
h-index: 0
机构:
Kochi Med Sch, Dept Pathol, Nankoku, Kochi, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Furihata, M.
;
Tamura, K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan
Kochi Med Sch, Dept Urol, Nankoku, Kochi, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Tamura, K.
;
Uemura, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Uemura, M.
;
Daigo, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Daigo, Y.
;
Nasu, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Okayama Univ, Sch Med, Dept Urol, Okayama 700, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Nasu, Y.
;
Miki, T.
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Prefectural Univ Med, Dept Urol, Kyoto, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Miki, T.
;
Shuin, T.
论文数: 0引用数: 0
h-index: 0
机构:
Kochi Med Sch, Dept Urol, Nankoku, Kochi, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Shuin, T.
;
Fujioka, T.
论文数: 0引用数: 0
h-index: 0
机构:
Iwate Med Univ, Dept Urol, Morioka, Iwate 020, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Fujioka, T.
;
Nakamura, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Nakamura, Y.
;
Nakagawa, H.
论文数: 0引用数: 0
h-index: 0
机构:
RIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, JapanRIKEN, Ctr Genom Med, Lab Biomarker Dev, Minato Ku, Tokyo 1088639, Japan
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Creighton, Chad J.
;
Casa, Angelo
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Casa, Angelo
;
Lazard, ZaWaunyka
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Lazard, ZaWaunyka
;
Huang, Shixia
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Huang, Shixia
;
Tsimelzon, Anna
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Tsimelzon, Anna
;
Hilsenbeck, Susan G.
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Hilsenbeck, Susan G.
;
Osborne, Charles Kent
论文数: 0引用数: 0
h-index: 0
机构:Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
Osborne, Charles Kent
;
Lee, Adrian V.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USABaylor Coll Med, Breast Ctr, Dept Med, Dan L Duncan Canc Ctr,Div Biostat, Houston, TX 77030 USA
机构:
Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Ho, Lye Lin
;
Kench, James G.
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, Australia
Westmead Hosp, Inst Clin Pathol & Med Res, Dept Tissue Pathol, Westmead, NSW 2145, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Kench, James G.
;
Handelsman, David J.
论文数: 0引用数: 0
h-index: 0
机构:
Concord Hosp, ANZAC Res Inst, Sydney, NSW, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Handelsman, David J.
;
Scheffer, George L.
论文数: 0引用数: 0
h-index: 0
机构:
Free Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, NetherlandsSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Scheffer, George L.
;
Stricker, Phillip D.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Urol, Sydney, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Stricker, Phillip D.
;
Grygiel, John G.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hospit, Dept Med Oncol, Sydney, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Grygiel, John G.
;
Sutherland, Robert L.
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Sutherland, Robert L.
;
Henshall, Susan M.
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Henshall, Susan M.
;
Allen, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Allen, John D.
;
Horvath, Lisa G.
论文数: 0引用数: 0
h-index: 0
机构:
Sydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia
Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, AustraliaSydney Canc Ctr, Dept Med Oncol RPAH, Camperdown, NSW 2050, Australia