Hemorheological effects of amlodipine in spontaneously hypertensive rats

被引:2
作者
Shamanaev, Aleksandr Y. [1 ]
Aliev, Oleg I. [1 ]
Anishchenko, Anna M. [1 ]
Sidehmenova, Anastasia V. [1 ]
Plotnikov, Mark B. [1 ]
机构
[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Dept Pharmacol, Tomsk, Russia
基金
俄罗斯科学基金会;
关键词
Amlodipine; arterial hypertension; hemorheology; spontaneously hypertensive rats; BLOOD RHEOLOGY; WHOLE-BLOOD; DYSFUNCTION; VISCOSITY;
D O I
10.4103/ijp.IJP_176_16
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
OBJECTIVES: The effect of course administration of amlodipine on whole blood viscosity and on macro- and microrheological parameters was evaluated. MATERIALS AND METHODS: SHRs were treated intragastrically with amlodipine at a dose of 10 mg/kg for 6 weeks. After finishing the course, hemodynamic and hemorheological parameters were measured. RESULTS: The antihypertensive treatment with amlodipine resulted in a significant decrease in mean blood pressure by 29% and left ventricular to body weight mass index by 7%. Nevertheless, BV tended to increase. The administration of amlodipine had no effect on PV, plasma fibrinogen concentration, RBC aggregation, and RBC deformability, but hematocrit was higher (by 6%) than it was in control group. CONCLUSIONS: These results demonstrate that amlodipine has no positive hemorheological improvements when administered to SHRs.
引用
收藏
页码:312 / 316
页数:5
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