Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

被引：42

作者：

Javier Garcia-Medina, Jose ^{[1
,2
,3
,4
,5
]}

Rubio-Velazquez, Elena ^{[1
]}

Foulquie-Moreno, Elisa ^{[1
]}

Casaroli-Marano, Ricardo P. ^{[5
,6
,7
,8
]}

Dolores Pinazo-Duran, Maria ^{[3
,4
,5
]}

Zanon-Moreno, Vicente ^{[9
]}

del-Rio-Vellosillo, Monica ^{[10
]}

机构：

[1] Gen Univ Hosp Morales Meseguer, Dept Ophthalmol, Murcia 30007, Spain

[2] Univ Murcia, Dept Ophthalmol & Optometry, Murcia 30120, Spain

[3] Ophthalm Res Unit Santiago Grisolia, Valencia 46017, Spain

[4] Univ Valencia, Cellular & Mol Ophthalmolobiol Grp, Surg Dept, Valencia 46010, Spain

[5] Inst Salud Carlos III, Red Temat Invest Cooperat Patol Ocular OFTARED, Madrid 28029, Spain

[6] Univ Barcelona, Dept Surg, Sch Med, E-08036 Barcelona, Spain

[7] Univ Barcelona, Hosp Clin Barcelona IDIBAPS, Sch Med, E-08036 Barcelona, Spain

[8] Inst Biomed Res IIB St Pau SGR1113, Banc Sang & Texits BST, E-08041 Barcelona, Spain

[9] Valencian Int Univ, Area Hlth Sci, Valencia 46002, Spain

[10] Univ Hosp Virgen Arrixaca, Dept Anaesthesiol, Murcia 30120, Spain

来源：

ANTIOXIDANTS | 2020年 / 9卷 / 06期

关键词：

diabetic retinopathy; antioxidant; oxidative stress; retina; in vitro; cell; animal; clinical trial; human; patient; RETINAL OXIDATIVE STRESS; DOXIUM CALCIUM DOBESILATE; CAPILLARY CELL-DEATH; DOUBLE-BLIND; BLOOD-FLOW; VITAMIN-E; METABOLIC ABNORMALITIES; INDUCED ACTIVATION; ENDOTHELIAL-CELLS; VISUAL FUNCTION;

D O I：

10.3390/antiox9060561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.

引用

页数：23

共 142 条

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