Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia-reperfusion injury

被引：18
作者：
Zhang, Ying [1 ,2 ]
Liu, Xiangrong [1 ,3 ]
Yan, Feng [1 ,3 ]
Min, Lianqiu [4 ]
Ji, Xunming [1 ,3 ]
Luo, Yumin [1 ,3 ]
机构：
[1] Capital Med Univ, Minist Educ, Xuanwu Hosp, Cerebrovasc Dis Res Inst, Beijing 100053, Peoples R China
[2] Capital Med Univ, Minist Educ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
[3] Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Dis, Beijing 100053, Peoples R China
[4] Liaoning Med Univ, Affiliated Hosp, Dept Neurol, Jinzhou 121000, Liaoning Provin, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 08期
基金：
中国国家自然科学基金;
关键词：
cerebral ischemia-reperfusion; remote ischemic preconditioning; stroke; neural regeneration; CHANNEL-DEPENDENT MECHANISM; CEREBRAL-ARTERY OCCLUSION; MYOCARDIUM; BRAIN; HEART; HUMANS; STROKE; CARDIOPROTECTION; DISTANCE; RABBIT;
D O I：
10.3969/j.issn.1673-5374.2012.00.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Three cycles of remote ischemic pre-conditioning induced by temporarily occluding the bilateral femoral arteries (10 minutes) prior to 10 minutes of reperfusion were given once a day for 3 days before the animal received middle artery occlusion and reperfusion surgery. The results showed that brain infarct volume was significantly reduced after remote ischemic pre-conditioning. Scores in the forelimb placing test and the postural reflex test were significantly lower in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. Thus, neurological function was better in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. These results indicate that remote ischemic pre-conditioning in rat hindlimb exerts protective effects in ischemia-reperfusion injury.
引用
收藏
页码：583 / 587
页数：5
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