Down syndrome and Alzheimer's disease: Common pathways, common goals

被引：199

作者：

Hartley, Dean ^{[1
]}

Blumenthal, Thomas ^{[2
,3
]}

Carrillo, Maria ^{[1
]}

DiPaolo, Gilbert ^{[4
,5
]}

Esralew, Lucille ^{[6
]}

Gardiner, Katheleen ^{[2
,7
]}

Granholm, Ann-Charlotte ^{[8
,9
]}

Iqbal, Khalid ^{[10
]}

Krams, Michael ^{[11
]}

Lemere, Cynthia ^{[12
,13
]}

Lott, Ira ^{[14
]}

Mobley, William ^{[15
]}

Ness, Seth ^{[11
]}

Nixon, Ralph ^{[16
]}

Potter, Huntington ^{[2
,17
]}

Reeves, Roger ^{[18
]}

Sabbagh, Marwan ^{[19
]}

Silverman, Wayne ^{[20
,21
]}

Tycko, Benjamin ^{[4
,5
]}

Whitten, Michelle ^{[22
]}

Wisniewski, Thomas ^{[23
]}

机构：

[1] Alzheimers Assoc, Med & Sci Relat, Chicago, IL 60631 USA

[2] Univ Colorado, Linda Crnic Inst Down Syndrome, Aurora, CO USA

[3] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

[4] Columbia Univ Med Ctr, Dept Pathol & Cell Biol, New York, NY USA

[5] Columbia Univ Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA

[6] Trinitas Reg Med Ctr, Dept Behav Hlth, Elizabeth, NJ USA

[7] Univ Colorado, Dept Pediat, Denver, CO 80202 USA

[8] Med Univ S Carolina, Dept Neurosci, Columbia, SC USA

[9] Med Univ S Carolina, Ctr Aging, Columbia, SC USA

[10] New York State Inst Basic Res Dev Disabil, Dept Neurochem, New York, NY USA

[11] Janssen Res & Dev, Raritan, NJ USA

[12] Harvard Univ, Sch Med, Dept Neurol, Brigham & Womens Hosp, Boston, MA 02115 USA

[13] Harvard Univ, Sch Med, Anne Romney Ctr Neurol Dis, Brigham & Womens Hosp, Boston, MA USA

[14] Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA

[15] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[16] NYU, Dept Psychiat & Cell Biol, Langone Med Ctr, New York, NY USA

[17] Univ Colorado, Dept Neurol, Denver, CO 80202 USA

[18] Johns Hopkins Univ Sch Med, McKusick Nathans Inst Genet Med, Dept Physiol, Baltimore, MD USA

[19] Banner Hlth, Banner Sun Hlth Res Inst, Sun City, AZ USA

[20] Kennedy Krieger Inst, Dept Behav Psychol, Baltimore, MD USA

[21] Johns Hopkins Univ Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA

[22] Global Down Syndrome Fdn, Denver, CO USA

[23] New York Univ, Langone Med Ctr, Dept Neurol Pathol & Psychiat, New York, NY USA

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 06期

关键词：

Down syndrome; Alzheimer's disease; Dementia; Animal models; Ts65Dn; Drug discovery; Neuroinflammation; Cognitive assessment; Amyloid precursor protein; Beta-amyloid; Tau; Clinical trials; Biomarkers; Trisomy; 21; ADNI; DS-Connect; Neuroimaging; Workshop; POSITRON-EMISSION-TOMOGRAPHY; AMYLOID PRECURSOR-PROTEIN; PITTSBURGH COMPOUND B; SYNDROME MOUSE MODEL; COGNITIVE DEFICITS; NEUROFIBRILLARY DEGENERATION; NEUROPATHOLOGICAL CHANGES; SECONDARY PREVENTION; BETA DEPOSITION; APP EXPRESSION;

D O I：

10.1016/j.jalz.2014.10.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the United States, estimates indicate there are between 250,000 and 400,000 individuals with Down syndrome (DS), and nearly all will develop Alzheimer's disease (AD) pathology starting in their 30s. With the current lifespan being 55 to 60 years, approximately 70% will develop dementia, and if their life expectancy continues to increase, the number of individuals developing AD will concomitantly increase. Pathogenic and mechanistic links between DS and Alzheimer's prompted the Alzheimer's Association to partner with the Linda Crnic Institute for Down Syndrome and the Global Down Syndrome Foundation at a workshop of AD and DS experts to discuss similarities and differences, challenges, and future directions for this field. The workshop articulated a set of research priorities: (1) target identification and drug development, (2) clinical and pathological staging, (3) cognitive assessment and clinical trials, and (4) partnerships and collaborations with the ultimate goal to deliver effective disease-modifying treatments. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：700 / 709

页数：10

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