The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release

被引:95
作者
Macleod, GS [1 ]
Collett, JH [1 ]
Fell, JT [1 ]
机构
[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England
关键词
polyelectrolyte complex (PEC); pectin USP; chitosan; viscosity;
D O I
10.1016/S0168-3659(98)00168-0
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Polyelectrolyte complex (PEC) formation between pectin USP and chitosan was investigated by examining the viscosities of supernatant solutions after removal of the precipitated complex. The amount of pectin, relative to chitosan, required for optimal PEC formation increased as the pH of the solution was reduced. At pH values of less than 1.3, there was no evidence for the formation of the PEG. Swelling studies conducted on pectin/chitosan films, showed minimal swelling occurring when the pectin:chitosan weight ratio was optimal for PEC formation, suggesting the formation of the PEC in situ. The permeability of the films to paracetamol as a model compound was dependent on film composition and was markedly increased after exposure to pectinolytic enzymes, used to mimic conditions in the colon. It may be implied from the results that similar formulations, applied as a film coat to tablets, could be used to achieve bimodal drug release with colonic conditions acting as a trigger for an increased rate of release. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:303 / 310
页数:8
相关论文
共 23 条
[11]   Hydrogel beads based on amidated pectins for colon-specific drug delivery: The role of chitosan in modifying drug release [J].
Munjeri, O ;
Collett, JH ;
Fell, JT .
JOURNAL OF CONTROLLED RELEASE, 1997, 46 (03) :273-278
[12]   Mechanical, water uptake and permeability properties of crosslinked chitosan glutamate and alginate films [J].
RemunanLopez, C ;
Bodmeier, R .
JOURNAL OF CONTROLLED RELEASE, 1997, 44 (2-3) :215-225
[13]  
RUBINSTEIN A, 1995, EUR J PHARM BIOPHARM, V41, P291
[14]   INVITRO EVALUATION OF CALCIUM PECTINATE - A POTENTIAL COLON-SPECIFIC DRUG DELIVERY CARRIER [J].
RUBINSTEIN, A ;
RADAI, R ;
EZRA, M ;
PATHAK, S ;
ROKEM, JS .
PHARMACEUTICAL RESEARCH, 1993, 10 (02) :258-263
[15]  
SAWAYANAGI Y, 1982, CHEM PHARM BULL, V30, P3297
[16]   CHARACTERISTICS OF POLYION COMPLEXES OF CHITOSAN WITH SODIUM ALGINATE AND SODIUM POLYACRYLATE [J].
TAKAHASHI, T ;
TAKAYAMA, K ;
MACHIDA, Y ;
NAGAI, T .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 61 (1-2) :35-41
[17]   In vitro degradation by colonic bacteria of inulinHP incorporated in Eudragit RS films [J].
Vervoort, L ;
Kinget, R .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 129 (1-2) :185-190
[18]   Pectin/ethylcellulose film coating formulations for colonic drug delivery [J].
Wakerly, Z ;
Fell, JT ;
Attwood, D ;
Parkins, D .
PHARMACEUTICAL RESEARCH, 1996, 13 (08) :1210-1212
[19]   Studies on drug release from pectin/ethylcellulose film-coated tablets: a potential colonic delivery system [J].
Wakerly, Z ;
Fell, JT ;
Attwood, D ;
Parkins, D .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 153 (02) :219-224
[20]   pH-sensitivity of the swelling of a chitosan-pectin polyelectrolyte complex [J].
Yao, KD ;
Tu, HL ;
Cheng, F ;
Zhang, JW ;
Liu, J .
ANGEWANDTE MAKROMOLEKULARE CHEMIE, 1997, 245 :63-72