High guest inclusion in 3β-amino-7α,12α-dihydroxycholan-24-oic acid enabled by charge-assisted hydrogen bonds

被引：14

作者：

Ryu, Eui-Hyun ^{[1
]}

Ellern, Arkady ^{[1
]}

Zhao, Yan ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 29期

关键词：

bile acids; crystal engineering; crystal structures; hydrogen bonds; inclusion compounds;

D O I：

10.1016/j.tet.2006.04.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3 beta-Amino-7 alpha,12 alpha-dihydroxycholan-24-oic acid (2) forms inclusion compounds with high ratio (host/guest=1/4) of guest methanol. Both hydrogen bonds and hydrophobic interactions are important to the solid structure. The cholates assemble in a head-to-tail fashion to form infinite hydrogen-bonded chains. The chains are interconnected between cholates and also through the guests. Large channels are formed along the crystallographic a axis where most of the methanol molecules are located. Presence of a dominant hydrogen-bonding motif (i.e., ammonium-carboxylate ion pairing) is probably responsible for high guest incorporation. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：6808 / 6813

页数：6

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