Focal therapy in prostate cancer: A review of seven common controversies

被引:23
作者
Bass, Edward J.
Ahmed, Hashim U.
机构
[1] UCL, Div Surg & Intervent Sci, London, England
[2] UCLH NHS Fdn Trust, Dept Urol, London, England
基金
英国医学研究理事会;
关键词
Prostate cancer; Focal therapy; Arguments for; Arguments against; RENAL-CELL CARCINOMA; QUALITY-OF-LIFE; ASSISTED RADICAL PROSTATECTOMY; NEPHRON-SPARING SURGERY; BREAST-CANCER; MULTIPARAMETRIC MRI; REFERENCE-STANDARD; MAPPING BIOPSIES; INDEX LESION; ULTRASOUND;
D O I
10.1016/j.ctrv.2016.07.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radical treatments such as prostatectomy and radiotherapy have demonstrated success in terms of biochemical and disease-specific survival for localised prostate cancer. However, whilst the end goal of any cancer treatment is to control or cure disease it must also do so by minimising any side effects that may be experienced by the patient. Focal therapy as a concept aims to redress this established therapeutic ratio by treating areas of the prostate affected by significant disease as opposed to treating the entire gland. However, there are a number of common criticisms of focal therapy - we deem the seven sins that require further interrogation. (C) 2016 Published by Elsevier Ltd.
引用
收藏
页码:27 / 34
页数:8
相关论文
共 75 条
[1]   Performance of multiparametric MRI in men at risk of prostate cancer before the first biopsy: a paired validating cohort study using template prostate mapping biopsies as the reference standard [J].
Abd-Alazeez, M. ;
Kirkham, A. ;
Ahmed, H. U. ;
Arya, M. ;
Anastasiadis, E. ;
Charman, S. C. ;
Freeman, A. ;
Emberton, M. .
PROSTATE CANCER AND PROSTATIC DISEASES, 2014, 17 (01) :40-46
[2]  
Abd-Alazeez M., 2014, Urol Oncol, V32, P45, DOI [DOI 10.1016/J.UR0L0NC.2013.06.007, 10.1016/j.urolonc.2013.06.007, DOI 10.1016/J.UROLONC.2013.06.007]
[3]   Can multiparametric magnetic resonance imaging predict upgrading of transrectal ultrasound biopsy results at more definitive histology? [J].
Abd-Alazeez, Mohamed ;
Ahmed, Hashim U. ;
Arya, Manit ;
Allen, Clare ;
Dikaios, Nikolaos ;
Freeman, Alex ;
Emberton, Mark ;
Kirkham, Alex .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2014, 32 (06) :741-747
[4]  
Acher P, 2014, BJU INT, V114, P28
[5]   Can we deliver randomized trials of focal therapy in prostate cancer? [J].
Ahmed, Hashim U. ;
Berge, Viktor ;
Bottomley, David ;
Cross, William ;
Heer, Rakesh ;
Kaplan, Richard ;
Leslie, Tom ;
Parker, Chris ;
Relton, Clare ;
Stephens, Richard ;
Sydes, Matthew R. ;
Turnbull, Lindsay ;
van der Meulen, Jan ;
Vickers, Andrew ;
Wilt, Timothy ;
Emberton, Mark .
NATURE REVIEWS CLINICAL ONCOLOGY, 2014, 11 (08) :482-491
[6]   Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy? [J].
Ahmed, Hashim Uddin ;
Arya, Manit ;
Freeman, Alex ;
Emberton, Mark .
LANCET ONCOLOGY, 2012, 13 (11) :E509-E517
[7]   Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy [J].
Ahmed, Hashim Uddin ;
Hu, Yipeng ;
Carter, Tim ;
Arumainayagam, Nimalan ;
Lecornet, Emilie ;
Freeman, Alex ;
Hawkes, David ;
Barratt, Dean C. ;
Emberton, Mark .
JOURNAL OF UROLOGY, 2011, 186 (02) :458-464
[8]   The Index Lesion and the Origin of Prostate Cancer [J].
Ahmed, Hashim Uddin .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (17) :1704-1706
[9]   Ten-Year Outcomes of High-Dose, Intensity-Modulated Radiotherapy for Localized Prostate Cancer [J].
Alicikus, Zumre A. ;
Yamada, Yoshiya ;
Zhang, Zhigang ;
Pei, Xin ;
Hunt, Margie ;
Kollmeier, Marisa ;
Cox, Brett ;
Zelefsky, Michael J. .
CANCER, 2011, 117 (07) :1429-1437
[10]  
[Anonymous], [No title captured], DOI DOI 10.1016/J.EURURO.2013.05.048