Obstructive Sleep Apnea Risk Is Associated with Cognitive Impairment after Controlling for Mild Traumatic Brain Injury History: A Chronic Effects of Neurotrauma Consortium Study

被引:8
作者
Garcia, Amanda [1 ,2 ]
Reljic, Tea [3 ]
Pogoda, Terri K. [6 ,7 ]
Kenney, Kimbra [8 ,9 ]
Agyemang, Amma [10 ]
Troyanskaya, Maya [11 ,12 ]
Belanger, Heather G. [4 ,13 ]
Wilde, Elisabeth A. [11 ,14 ,15 ]
Walker, William C. [10 ]
Nakase-Richardson, Risa [1 ,2 ,5 ]
机构
[1] James A Haley VA Hosp, Def & Vet Brain Injury Ctr, 13000 Bruce B Downs Blvd, Tampa, FL 33612 USA
[2] James A Haley VA Hosp, Mental Hlth & Behav Sci, Tampa, FL USA
[3] Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA
[4] Univ S Florida, Dept Psychol & Psychiat & Behav Neurosci, Tampa, FL 33620 USA
[5] Univ S Florida, Dept Internal Med, Sleep & Pulm Div, Tampa, FL 33620 USA
[6] VA Boston Healthcare Syst, Ctr Healthcare Org & Implementat Res, Boston, MA USA
[7] Boston Univ, Sch Publ Hlth, Boston, MA USA
[8] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA
[9] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD USA
[10] Virginia Commonwealth Univ, Dept Phys Med & Rehabil, Richmond, VA USA
[11] Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA
[12] Michael E DeBakey VA Med Ctr, Houston, TX USA
[13] United States Special Operat Command, Tampa, FL USA
[14] George E Wahlen VA Salt Lake City Healthcare Syst, Salt Lake City, UT USA
[15] Univ Utah, Dept Neurol, TBI & Concuss, Salt Lake City, UT USA
关键词
chronic effects; cognition; mild traumatic brain injury; military; mTBI; neurotrauma; obstructive sleep apnea; OSA; EDITION CVLT-II; NEUROPSYCHOLOGICAL OUTCOMES; SYMPTOMS; METAANALYSIS; INDIVIDUALS; RECOVERY; INSOMNIA; QUESTIONNAIRE; RELIABILITY; DEPRIVATION;
D O I
10.1089/neu.2019.6916
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The contribution of sleep disturbance to persistent cognitive symptoms following a mild traumatic brain injury (mTBI) remains unclear. Obstructive sleep apnea (OSA) is very common, yet its relationship between risk factors for developing OSA and cognitive performance in those with history of mTBI has not been investigated. The current study examined OSA risk levels and its association with cognitive performance in 391 combat-exposed, post-911 veterans and service members (median age = 37 years) enrolled in the Chronic Effects of Neurotrauma Consortium (CENC) prospective multi-center study. Participants included those with and without mTBI (n = 326 and 65, respectively). When using clinical cut-offs, those with history of mTBI were more likely to be categorized as high risk for OSA (mTBI positive = 65% vs. mTBI negative = 51%). After adjustment for TBI status and demographic variables, increased OSA risk was significantly associated with worse performance on measures of complex processing speed and executive functioning (Wechsler Adult Intelligence Scale Fourth EditionCoding, Trail Making Test, part B) and greater symptom burden (Neurobehavioral Symptom Inventory). Thus, OSA, a modifiable behavioral health factor, likely contributes to cognitive performance following mTBI. Accordingly, OSA serves as a potential point of intervention to improve clinical and cognitive outcomes after injury.
引用
收藏
页码:2517 / 2527
页数:11
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