Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro

被引：146
作者：
Heng, BC
Haider, HK
Sim, EKW
Cao, T
Ng, SC
机构：
[1] Natl Univ Singapore, Fac Med, Dept Obstet & Gynaecol, Singapore 119074, Singapore
[2] Natl Univ Singapore, Fac Med, Dept Surg, Div Cardiothorac Vasc Surg, Singapore 119074, Singapore
[3] Natl Univ Singapore, Fac Dent, Cell & Tissue Culture Lab, Singapore 119074, Singapore
来源：
CARDIOVASCULAR RESEARCH | 2004年 / 62卷 / 01期
关键词：
stem cells; differentiation; myocardial infarction; cardiomyocytes; transplantation;
D O I：
10.1016/j.cardiores.2003.12.022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to transplantation would result in higher engraftment efficiency, as well as enhanced myocardial regeneration and recovery of heart function. Additionally, this may also alleviate the probability of spontaneous differentiation of stem cells into undesired lineages and reduces the risk of teratoma formation, in the case of embryonic stem cells. The development of efficient protocols for directing the cardiomyogenic differentiation of stem cells in vitro will also provide a useful model for molecular studies and genetic manipulation. This review therefore critically examines the various techniques that could possibly be used to direct and control the cardiomyogenic differentiation of stem cells in vitro. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：34 / 42
页数：9
相关论文
共 97 条
[41]   Multilineage differentiation of human MSC after in utero transplantation [J].
Mackenzie, TC ;
Flake, AW .
CYTOTHERAPY, 2001, 3 (05) :403-405
[42]   EMBRYONIC STEM-CELLS DIFFERENTIATE IN-VITRO INTO CARDIOMYOCYTES REPRESENTING SINUSNODAL, ATRIAL AND VENTRICULAR CELL-TYPES [J].
MALTSEV, VA ;
ROHWEDEL, J ;
HESCHELER, J ;
WOBUS, AM .
MECHANISMS OF DEVELOPMENT, 1993, 44 (01) :41-50
[43]  
Matsushita T, 1999, CIRC RES, V85, P1046
[44]   CONTROL OF MUSCLE AND NEURONAL DIFFERENTIATION IN A CULTURED EMBRYONAL CARCINOMA CELL-LINE [J].
MCBURNEY, MW ;
JONESVILLENEUVE, EMV ;
EDWARDS, MKS ;
ANDERSON, PJ .
NATURE, 1982, 299 (5879) :165-167
[45]   Ventricular remodeling: Hype or hope? [J].
McCarthy, PM .
NATURE MEDICINE, 1996, 2 (08) :859-860
[46]   Mechanical circulatory support - a long and winding road [J].
McCarthy, PM ;
Smith, WA .
SCIENCE, 2002, 295 (5557) :998-999
[47]   Differentiation of human embryonic stem cells to cardiomyocytes - Role of coculture with visceral endoderm-like cells [J].
Mummery, C ;
Ward-van Oostwaard, D ;
Doevendans, P ;
Spijker, R ;
van den Brink, S ;
Hassink, R ;
van der Heyden, M ;
Opthof, T ;
Pera, M ;
de la Riviere, AB ;
Passier, R ;
Tertoolen, L .
CIRCULATION, 2003, 107 (21) :2733-2740
[48]   Cardiomyocyte differentiation of mouse and human embryonic stem cells [J].
Mummery, C ;
Ward, D ;
van den Brink, CE ;
Bird, SD ;
Doevendans, PA ;
Opthof, T ;
de la Riviere, AB ;
Tertoolen, L ;
van der Heyden, M ;
Pera, M .
JOURNAL OF ANATOMY, 2002, 200 (03) :233-242
[49]   Multilineage differentiation from human embryonic stem cell lines [J].
Odorico, JS ;
Kaufman, DS ;
Thomson, JA .
STEM CELLS, 2001, 19 (03) :193-204
[50]   Mobilized bone marrow cells repair the infarcted heart, improving function and survival [J].
Orlic, D ;
Kajstura, J ;
Chimenti, S ;
Limana, F ;
Jakoniuk, I ;
Quaini, F ;
Nadal-Ginard, B ;
Bodine, DM ;
Leri, A ;
Anversa, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10344-10349
12345678910