Bicyclic guanidinium-catalyzed enantioselective phase-transfer alkylation: direct access to pyrroloindolines and furoindolines

被引：36

作者：

Chen, Wenchao ^{[1
]}

Yang, Wenguo ^{[1
]}

Yan, Lin ^{[1
]}

Tan, Choon-Hong ^{[2
]}

Jiang, Zhiyong ^{[1
,2
]}

机构：

[1] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China

[2] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 84期

关键词：

CONCISE TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; CONSTRUCTION; OXINDOLES; ALKALOIDS; MICHAEL; COMPLEX;

D O I：

10.1039/c3cc46111d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective phase-transfer alkylation of 3-substituted-2-oxindoles with activated bromomethanes is disclosed with a broad substrate scope by using bicyclic guanidinium as a catalyst and a Lewis acid as the co-catalyst. The alkylation adducts are versatile intermediates to accomplish the syntheses of pyrroloindolines and furoindolines.

引用

页码：9854 / 9856

页数：3

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