Bicyclic guanidinium-catalyzed enantioselective phase-transfer alkylation: direct access to pyrroloindolines and furoindolines

被引：33
作者：
Chen, Wenchao [1 ]
Yang, Wenguo [1 ]
Yan, Lin [1 ]
Tan, Choon-Hong [2 ]
Jiang, Zhiyong [1 ,2 ]
机构：
[1] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China
[2] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 84期
关键词：
CONCISE TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; CONSTRUCTION; OXINDOLES; ALKALOIDS; MICHAEL; COMPLEX;
D O I：
10.1039/c3cc46111d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly enantioselective phase-transfer alkylation of 3-substituted-2-oxindoles with activated bromomethanes is disclosed with a broad substrate scope by using bicyclic guanidinium as a catalyst and a Lewis acid as the co-catalyst. The alkylation adducts are versatile intermediates to accomplish the syntheses of pyrroloindolines and furoindolines.
引用
收藏
页码：9854 / 9856
页数：3
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