Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

被引：102
作者：
El Aamri, Maliana [1 ]
Yammouri, Ghita [1 ]
Mohammadi, Hasna [1 ]
Amine, Aziz [1 ]
Korri-Youssoufi, Hafsa [2 ]
机构：
[1] Univ Casablanca, Hassan II, Lab Proc Engn & Environm, Fac Sci & Tech, BP 146, Mohammadia 28806, Morocco
[2] Univ Paris Saclay, CNRS, Inst Chim Mol & Mat Orsay ICMMO, Equipe Chim Biorgan & Bioinorgan ECBB, Bat 420,2 Rue Doyen Georges Poitou, F-91400 Orsay, France
来源：
BIOSENSORS-BASEL | 2020年 / 10卷 / 11期
关键词：
microRNA; electrochemical biosensor; catalysts; RedOx indicator; cancer biomarker; DUPLEX-SPECIFIC NUCLEASE; SIGNAL AMPLIFICATION STRATEGY; HIGHLY SENSITIVE DETERMINATION; ROLLING CIRCLE AMPLIFICATION; STRAND DISPLACEMENT REACTION; HYBRIDIZATION CHAIN-REACTION; TARGET RECYCLING AMPLIFICATION; WALLED CARBON NANOTUBES; BREAST-CANCER; ULTRASENSITIVE DETECTION;
D O I：
10.3390/bios10110186
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted.
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页数：46
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