Genetic heterogeneity in breast cancer: the road to personalized medicine?

被引：45

作者：

Baird, Richard D. ^{[1
]}

Caldas, Carlos ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Oncol, Addenbrookes Hosp, Cambridge CB4 3EJ, England

[2] Cancer Res UK Cambridge Res Inst, Li KaShing Ctr, Cambridge CB2 0RE, England

来源：

BMC MEDICINE | 2013年 / 11卷

关键词：

Breast cancer; Next-generation sequencing; Whole-genome sequencing; Molecular profiling; Personalized medicine; Heterogeneity; MUTATIONAL EVOLUTION; GENOMES; RESISTANCE; THERAPY; REVEALS;

D O I：

10.1186/1741-7015-11-151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time.

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