lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference

被引：38

作者：

Smekalova, Elena M. ^{[1
]}

Kotelevtsev, Yuri V. ^{[2
]}

Leboeuf, Dominique ^{[2
]}

Shcherbinina, Evgeniya Y. ^{[2
]}

Fefilova, Anna S. ^{[2
]}

Zatsepin, Timofei S. ^{[2
,3
,4
]}

Koteliansky, Victor ^{[2
,3
]}

机构：

[1] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] Skolkovo Inst Sci & Technol, 4 Alfred Nobel St, Skolkovo 143025, Russia

[3] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119992, Russia

[4] Cent Res Inst Epidemiol, Novogireevskaya 3a, Moscow 111123, Russia

来源：

BIOCHIMIE | 2016年 / 131卷

基金：

俄罗斯科学基金会;

关键词：

Long noncoding RNA (lncRNA); Delivery; siRNA; Liver; GalNAc conjugate; Lipid nanoparticle (LNP); Endosome escape; RNAi; Hepatocellular carcinoma; LONG NONCODING RNA; IN-VIVO DELIVERY; HEPATOCELLULAR-CARCINOMA METASTASIS; APTAMER-SIRNA CHIMERAS; ASIALOGLYCOPROTEIN RECEPTOR; LIPID NANOPARTICLES; GENE-EXPRESSION; CELLULAR UPTAKE; ANTISENSE OLIGONUCLEOTIDES; INTRACELLULAR TRAFFICKING;

D O I：

10.1016/j.biochi.2016.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs constitute the most abundant part of the transcribed mammalian genome. lncRNAs affect all essential processes in the living cell including transcription, splicing, translation, replication, shaping of chromatin and post translational modification of proteins. Alterations in lncRNA expression have been linked to a number of diseases; thus, modulation of lncRNA expression holds a huge potential for gene-based therapy. In this review we summarize published data about lncRNAs in the context of hepatic carcinogenesis and liver fibrosis, and the corresponding potential targets for gene therapy. Recent advancements in targeted delivery to the liver made RNA interference an invaluable tool to decipher hepatic lncRNA function and to develop lncRNA-oriented therapies for liver-involved diseases in the future. Different approaches for RNA delivery that can be used for functional studies in the lab and for clinical lncRNA based applications are critically discussed in this review. Published by Elsevier B.V.

引用

页码：159 / 172

页数：14

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