AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer

被引：4
作者：
Chen, Ruibao [1 ,2 ]
Luan, Yang [1 ,2 ]
Liu, Zhuo [1 ,2 ]
Song, Wen [1 ,2 ]
Wu, Licheng [1 ,2 ]
Li, Mingchao [1 ,2 ]
Yang, Jun [1 ,2 ]
Liu, Xiaming [1 ,2 ]
Wang, Tao [1 ,2 ]
Liu, Jihong [1 ,2 ]
Ye, Zhangqun [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Urol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Inst Urol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
基金：
中国国家自然科学基金;
关键词：
ANDROGEN RECEPTOR; EXPRESSION;
D O I：
10.1155/2015/514234
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
CX43 plays a critical role in tumor progression. Previous studies imply that AR pathway may be involved in regulation of CX43. This study was focused on determining the relationship between AR pathway and CX43. The result showed that the expression of CX43 in malignant cells was higher than that in normal cells, and in nonmalignant and malignant cells, not only is the expression level of CX43 different, but the localization of CX43 can also be changed. After androgen stimulation and inhibition of AR pathway, expression of CX43 can also be changed. Thus, AR pathway plays an important role in regulation of CX43 expression in prostate cancer cells. AR may be the upstream signal of CX43.
引用
收藏
页数：6
相关论文
共 14 条
  • [1] Prognostic value of connexin43 expression in patients with clinically localized prostate cancer
    Benko, G.
    Spajic, B.
    Demirovic, A.
    Stimac, G.
    Kruslin, B.
    Tomas, D.
    [J]. PROSTATE CANCER AND PROSTATIC DISEASES, 2011, 14 (01) : 90 - 95
  • [2] Increase of gap junction activities in SW480 human colorectal cancer cells
    Bigelow, Kristina
    Nguyen, Thu A.
    [J]. BMC CANCER, 2014, 14
  • [3] Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers
    Chen, Ruibao
    Zeng, Xing
    Zhang, Ruitao
    Huang, Jiaoti
    Kuang, Xiangxing
    Yang, Jun
    Liu, Jihong
    Tawfik, Ossama
    Thrasher, James Brantley
    Li, Benyi
    [J]. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2014, 32 (05) : 524 - 536
  • [4] Up-regulation of VEGF by Small Activator RNA in Human Corpus Cavernosum Smooth Muscle Cells
    Chen, Ruibao
    Wang, Tao
    Rao, Ke
    Yang, Jun
    Zhang, Shilin
    Wang, Shaogang
    Liu, Jihong
    Ye, Zhangqun
    [J]. JOURNAL OF SEXUAL MEDICINE, 2011, 8 (10) : 2773 - 2780
  • [5] New insights into prostate cancer stem cells
    Chen, Xin
    Rycaj, Kiera
    Liu, Xin
    Tang, Dean G.
    [J]. CELL CYCLE, 2013, 12 (04) : 579 - 586
  • [6] Targeting the Androgen Receptor
    Friedlander, Terence W.
    Ryan, Charles J.
    [J]. UROLOGIC CLINICS OF NORTH AMERICA, 2012, 39 (04) : 453 - +
  • [7] Pathological Implications of Cx43 Down-regulation in Human Colon Cancer
    Ismail, Rehana
    Rashid, Rabiya
    Andrabi, Khurshid
    Parray, Fazl Q.
    Besina, Syed
    Shah, Mohd Amin
    Ul Hussain, Mahboob
    [J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (07) : 2987 - 2991
  • [8] Suppression of CX43 expression by miR-20a in the progression of human prostate cancer
    Li, Xin
    Pan, Jin-Hong
    Song, Bo
    Xiong, En-Qing
    Chen, Zhi-Wen
    Zhou, Zhan-Song
    Su, Yong-Ping
    [J]. CANCER BIOLOGY & THERAPY, 2012, 13 (10) : 890 - 898
  • [9] Androgen receptor is a tumor suppressor and proliferator in prostate cancer
    Niu, Yuanjie
    Altuwaijri, Saleh
    Lai, Kuo-Pao
    Wu, Chun-Te
    Ricke, William A.
    Messing, Edward M.
    Yao, Jorge
    Yeh, Shuyuan
    Chang, Chawnshang
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (34) : 12182 - 12187
  • [10] Prostate Cancer Stem Cells
    Tu, Shi-Ming
    Lin, Sue-Hwa
    [J]. CLINICAL GENITOURINARY CANCER, 2012, 10 (02) : 69 - 76
12