Synthesis of Novel Enantiopure Biphenyl P,N-Ligands and Application in Palladium-Catalyzed Asymmetric Addition of Arylboronic Acids to N-Benzylisatin

被引：112

作者：

Lai, Hongshan

Huang, Zhiyan

Wu, Qiong

Qin, Yong ^{[1
]}

机构：

[1] Sichuan Univ, Minist Educ, Key Lab Drug Targeting & Novel Delivery Syst, Dept Chem Med Nat Prod,W China Sch Pharm, Chengdu 610041, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 01期

关键词：

ARYL HALIDES; ALLYLIC SUBSTITUTION; BINAPHTHYL BACKBONE; CHIRAL LIGANDS; MAP LIGANDS; COMPLEXES; VERSATILE; EFFICIENT; AMINOCARBONYLATION; DERIVATIVES;

D O I：

10.1021/jo802036m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiopure tetra-ortho-substituted biphenyl phosphinoimine ligands (R-a,S)-3 and (S-a,S)-3 were synthesized via multistep reactions. The first asymmetric addition reactions of arylboronic acids to N-benzylisatin catalyzed by Pd(OAC)(2) and (R-a,S)-3 were Studied to provide 3-aryl-3-hydroxyoxindoles in moderate yields and enantioselectivities.

引用

页码：283 / 288

页数：6

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