Isotope dilution high-performance liquid chromatography/tandem mass spectrometry method for quantifying urinary metabolites of atrazine, malathion, and 2,4-dichlorophenoxyacetic acid

被引：56

作者：

Beeson, MD ^{[1
]}

Driskell, WJ ^{[1
]}

Barr, DB ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA

来源：

ANALYTICAL CHEMISTRY | 1999年 / 71卷 / 16期

关键词：

D O I：

10.1021/ac990130u

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have developed an isotope dilution high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) method for quantifying the urinary metabolites of the pesticides atrazine, malathion, and 2,4-dichlorophenoxyacetic acid (2,4-D). Urine samples are extracted with an organic solvent, and the organic fraction is concentrated. The concentrate is then analyzed using HPLC/MS/MS. The limits of detection for the metabolites are less than 0.5 mu g/L (parts per billion) in 10 mL of urine, with a high degree of accuracy and precision.

引用

页码：3526 / 3530

页数：5

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