Relationship Between ACE2 and Other Components of the Renin-Angiotensin System

被引：16
|
作者：
Cohen, Jordana B. [1 ,2 ]
Hanff, Thomas C. [2 ,3 ]
Bress, Adam P. [4 ]
South, Andrew M. [5 ,6 ,7 ,8 ]
机构：
[1] Univ Penn, Dept Med, Perelman Sch Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Med, Perelman Sch Med, Div Cardiol, Philadelphia, PA 19104 USA
[4] Univ Utah, Dept Populat Hlth Sci, Div Hlth Syst Innovat & Res, Salt Lake City, UT USA
[5] Wake Forest Sch Med, Dept Pediat, Sect Nephrol, Winston Salem, NC 27101 USA
[6] Brenner Childrens Hosp, Winston Salem, NC USA
[7] Wake Forest Sch Med, Div Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27101 USA
[8] Wake Forest Sch Med, Dept Surg Hypertens & Vasc Res, Winston Salem, NC 27101 USA
来源：
CURRENT HYPERTENSION REPORTS | 2020年 / 22卷 / 07期
关键词：
COVID-19; Angiotensin-converting enzyme; Renin-angiotensin system; Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; Hypertension; Coronavirus infections; Chronic kidney disease; Cardiovascular disease; CONVERTING ENZYME-2 ACE2; CLINICAL CHARACTERISTICS; INHIBITION; EXPRESSION; BLOCKADE; FIBROSIS; INJURY; AXIS;
D O I：
10.1007/s11906-020-01048-y
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Purpose of the Review Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. Recent Findings ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
    Jordana B. Cohen
    Thomas C. Hanff
    Adam P. Bress
    Andrew M. South
    Current Hypertension Reports, 2020, 22
  • [2] ACE2: a key modulator of the renin-angiotensin system and pregnancy
    Tamanna, Sonia
    Lumbers, Eugenie R.
    Morosin, Saije K.
    Delforce, Sarah J.
    Pringle, Kirsty G.
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2021, 321 (06) : R833 - R843
  • [3] The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients
    Zamai, Loris
    CELLS, 2020, 9 (07) : 1 - 35
  • [4] Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
    Jiang, Xiao
    Eales, James M.
    Scannali, David
    Nazgiewicz, Alicja
    Prestes, Priscilla
    Maier, Michelle
    Denniff, Matthew
    Xu, Xiaoguang
    Saluja, Sushant
    Cano-Gamez, Eddie
    Wystrychowski, Wojciech
    Szulinska, Monika
    Antczak, Andrzej
    Byars, Sean
    Skrypnik, Damian
    Glyda, Maciej
    Krol, Robert
    Zywiec, Joanna
    Zukowska-Szczechowska, Ewa
    Burrell, Louise M.
    Woolf, Adrian S.
    Greenstein, Adam
    Bogdanski, Pawel
    Keavney, Bernard
    Morris, Andrew P.
    Heagerty, Anthony
    Williams, Bryan
    Harrap, Stephen B.
    Trynka, Gosia
    Samani, Nilesh J.
    Guzik, Tomasz J.
    Charchar, Fadi J.
    Tomaszewski, Maciej
    EUROPEAN HEART JOURNAL, 2020, 41 (48) : 4580 - 4588
  • [5] THE ROLE OF RENIN-ANGIOTENSIN SYSTEM AND ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) IN THE DEVELOPMENT AND COURSE OF VIRAL INFECTION COVID-19 IN PATIENTS WITH DIABETES MELLITUS
    Vikulova, Olga K.
    Zuraeva, Zamira T.
    Nikankina, Liudmila, V
    Shestakova, Marina, V
    DIABETES MELLITUS, 2020, 23 (03): : 242 - 249
  • [6] ACE2, the Counter-Regulatory Renin-Angiotensin System Axis and COVID-19 Severity
    Triposkiadis, Filippos
    Xanthopoulos, Andrew
    Giamouzis, Grigorios
    Boudoulas, Konstantinos Dean
    Starling, Randall C.
    Skoularigis, John
    Boudoulas, Harisios
    Iliodromitis, Efstathios
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (17)
  • [7] Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2)
    Zemlin, Annalise E.
    Wiese, Owen J.
    ANNALS OF CLINICAL BIOCHEMISTRY, 2020, 57 (05) : 339 - 350
  • [8] New pathways of the renin-angiotensin system: the role of ACE2 in cardiovascular pathophysiology and therapy
    Castro-Chaves, Paulo
    Cerqueira, Rui
    Pintalhao, Mariana
    Leite-Moreira, Adelino F.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2010, 14 (05) : 485 - 496
  • [9] The Relationship between the Intrarenal Dopamine System and Intrarenal Renin-angiotensin System Depending on the Renal Function
    Matsuyama, Takashi
    Ohashi, Naro
    Ishigaki, Sayaka
    Isobe, Shinsuke
    Tsuji, Naoko
    Fujikura, Tomoyuki
    Tsuji, Takayuki
    Kato, Akihiko
    Miyajima, Hiroaki
    Yasuda, Hideo
    INTERNAL MEDICINE, 2018, 57 (22) : 3241 - 3247
  • [10] Downregulation of ACE2 induces overstimulation of the renin-angiotensin system in COVID-19: should we block the renin-angiotensin system?
    Silhol, Francois
    Sarlon, Gabrielle
    Deharo, Jean-Claude
    Vaisse, Bernard
    HYPERTENSION RESEARCH, 2020, 43 (08) : 854 - 856
12345