MALVAC 2012 scientific forum: accelerating development of second-generation malaria vaccines

被引：19

作者：

Vannice, Kirsten S. ^{[2
]}

Brown, Graham V. ^{[3
]}

Akanmori, Bartholomew D. ^{[4
]}

Moorthy, Vasee S. ^{[1
]}

机构：

[1] World Hlth Org, Initiat Vaccine Res, Dept Immunizat Vaccines & Biol, Ave Appia 20, CH-1211 Geneva 27, Switzerland

[2] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[3] Univ Melbourne, Nossal Inst Global Hlth, Carlton, Vic 3010, Australia

[4] WHO Reg Off Africa, Immunizat & Vaccines Dev Programme, Div Prevent & Control Communicable Dis, Brazzaville, Rep Congo

来源：

MALARIA JOURNAL | 2012年 / 11卷

关键词：

Global; Malaria; WHO; Malaria vaccine; Elimination; Vaccine research; Surveillance; Clinical trials; Field trials; POPULATIONS;

D O I：

10.1186/1475-2875-11-372

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The World Health Organization (WHO) convened a malaria vaccines committee (MALVAC) scientific forum from 20 to 21 February 2012 in Geneva, Switzerland, to review the global malaria vaccine portfolio, to gain consensus on approaches to accelerate second-generation malaria vaccine development, and to discuss the need to update the vision and strategic goal of the Malaria Vaccine Technology Roadmap. This article summarizes the forum, which included reviews of leading Plasmodium falciparum vaccine candidates for pre-erythrocytic vaccines, blood-stage vaccines, and transmission-blocking vaccines. Other major topics included vaccine candidates against Plasmodium vivax, clinical trial site capacity development in Africa, trial design considerations for a second-generation malaria vaccine, adjuvant selection, and regulatory oversight functions including vaccine licensure.

引用

页数：10

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