Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

被引：125

作者：

Wyres, Kelly L. ^{[1
]}

Hawkey, Jane ^{[1
]}

Hetland, Marit A. K. ^{[2
]}

Fostervold, Aasmund ^{[2
,3
]}

Wick, Ryan R. ^{[1
]}

Judd, Louise M. ^{[1
]}

Hamidian, Mohammad ^{[4
]}

Howden, Benjamin P. ^{[5
]}

Lohr, Iren H. ^{[2
]}

Holt, Kathryn E. ^{[1
,6
]}

机构：

[1] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Dept Biochem & Mol Biol, Parkville, Vic, Australia

[2] Stavanger Univ Hosp, Dept Med Microbiol, Stavanger, Norway

[3] Univ Bergen, Dept Clin Sci, Bergen, Norway

[4] Univ Technol Sydney, Ithree Inst, Ultimo, NSW, Australia

[5] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Microbiol Diagnost Unit,Publ Hlth Lab, Parkville, Vic, Australia

[6] London Sch Hyg & Trop Med, London, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2019年 / 74卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

SOUTH-KOREA; ENTEROBACTERIACEAE; SURVEILLANCE; EXPANSION; HOSPITALS;

D O I：

10.1093/jac/dky492

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results We show that ST307 emerged in the mid-1990s (nearly 20years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the bla(CTX-M-15) ESBL gene and several other AMR determinants. Conclusions Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.

引用

页码：577 / 581

页数：5

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