Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

被引：98

作者：

Volpi, Simona ^{[1
]}

Bult, Carol J. ^{[2
]}

Chisholm, Rex L. ^{[3
]}

Deverka, Patricia A. ^{[4
]}

Ginsburg, Geoffrey S. ^{[5
]}

Jacob, Howard J. ^{[6
]}

Kasapi, Melpomeni ^{[1
]}

McLeod, Howard L. ^{[7
]}

Roden, Dan M. ^{[8
]}

Williams, Marc S. ^{[9
]}

Green, Eric D. ^{[1
]}

Rodriguez, Laura Lyman ^{[1
]}

Aronson, Samuel ^{[10
]}

Cavallari, Larisa H. ^{[11
,12
]}

Denny, Joshua C. ^{[13
]}

Dressler, Lynn G. ^{[14
]}

Johnson, Julie A. ^{[11
,12
]}

Klein, Teri E. ^{[15
]}

Leeder, J. Steven ^{[16
]}

Piquette-Miller, Micheline ^{[17
]}

Perera, Minoli ^{[18
]}

Rasmussen-Torvik, Laura J. ^{[19
]}

Rehm, Heidi L. ^{[20
,21
]}

Ritchie, Marylyn D. ^{[22
]}

Skaar, Todd C. ^{[23
]}

Wagle, Nikhil ^{[24
]}

Weinshilboum, Richard ^{[25
,26
]}

Weitzel, Kristin W. ^{[27
]}

Wildin, Robert ^{[28
,29
]}

Wilson, John ^{[30
]}

Manolio, Teri A. ^{[1
]}

Relling, Mary V. ^{[31
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] Jackson Lab Mammalian Genet, Bar Harbor, ME USA

[3] Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA

[4] Amer Inst Res, Washington, DC USA

[5] Duke Univ, Duke Ctr Appl Genom & Precis Med, Durham, NC USA

[6] HudsonAlpha Inst Biotechnol, Huntsville, AL USA

[7] H Lee Moffitt Canc Ctr & Res Inst, DeBartolo Family Personalized Med Inst, Tampa, FL USA

[8] Vanderbilt Univ, Med Ctr, Dept Med Pharmacol & Biomed Informat, Nashville, TN USA

[9] Geisinger, Genom Med Inst, Danville, PA USA

[10] Partners Healthcare, Cambridge, MA USA

[11] Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA

[12] Univ Florida, Ctr Pharmacogen, Gainesville, FL USA

[13] Vanderbilt Univ, Dept Biomed Informat & Med, 221 Kirkland Hall, Nashville, TN 37235 USA

[14] Mission Hlth, Personalized Med Program, Asheville, NC USA

[15] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[16] Childrens Mercy Hosp, Div Clin Pharmacol Toxicol & Therapeut Innovat, Kansas City, MO 64108 USA

[17] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada

[18] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA

[19] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA

[20] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[21] Harvard Med Sch, Boston, MA USA

[22] Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[23] Indiana Univ Sch Med, Dept Clin Pharmacol, Indianapolis, IN 46202 USA

[24] Dana Farber Canc Inst, Boston, MA 02115 USA

[25] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[26] Mayo Clin, Ctr Individualized Med, Rochester, MN USA

[27] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA

[28] Univ Vermont, Med Ctr, Dept Pathol & Lab Med, Burlington, VT USA

[29] Univ Vermont, Med Ctr, Dept Pediat, Burlington, VT USA

[30] Optum, Eden Prairie, MN USA

[31] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 103卷 / 05期

关键词：

PERSONALIZED MEDICINE; COST-EFFECTIVENESS; GENOMIC MEDICINE; CARE; RECOMMENDATIONS; CONSORTIUM; THERAPY; DESIGN; HEALTH; FUTURE;

D O I：

10.1002/cpt.1048

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing. Here we survey the US landscape of research programs in PGx implementation, review current advances and clinical applications of PGx, summarize the obstacles that have hindered PGx implementation, and identify the critical knowledge gaps and possible studies needed to help to address them.

引用

页码：778 / 786

页数：9