Targeting IRF4 in autoimmune diseases

被引：72
|
作者：
Xu, Wang-Dong [1 ]
Pan, Hai-Feng [1 ]
Ye, Dong-Qing [1 ]
Xu, Yuekang [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China
[2] Univ Melbourne, Inst Bio21, Dept Biochem & Mol Biol, Melbourne, Vic 3010, Australia
来源：
AUTOIMMUNITY REVIEWS | 2012年 / 11卷 / 12期
基金：
英国医学研究理事会; 中国国家自然科学基金;
关键词：
Interferon regulatory factor 4; Immune cells; Immune response; Autoimmune diseases; INTERFERON-REGULATORY FACTOR-4; PLASMA-CELL DIFFERENTIATION; TRANSCRIPTION FACTOR IRF4; CD4(+) T-CELLS; CENTER B-CELLS; LYMPHOCYTE DIFFERENTIATION; GENE-EXPRESSION; EXPERIMENTAL COLITIS; CYTOKINE PRODUCTION; DENDRITIC CELLS;
D O I：
10.1016/j.autrev.2012.08.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
As a member of the IRF family of transcription factors, interferon regulatory factor 4 (IRF4) is expressed in most cell types of the immune system. Recent findings suggest that IRF4 is essential for the development and function of T helper (Th) cell, regulatory T (Treg) cell, B cell, as well as dendritic cell (DC). Since these cells are crucial in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), and type I diabetes, the roles of IRF4 in the initiation and progression of autoimmune diseases can not be neglected. In this review, we summarize recent advances on the pathological roles of IRF4 in autoimmunity and discuss the therapeutic significance of these new findings. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：918 / 924
页数：7
相关论文
共 50 条
  • [41] IRF4 is a novel mediator for neuronal survival in ischaemic stroke
    S Guo
    Z-Z Li
    D-S Jiang
    Y Y Lu
    Y Liu
    L Gao
    S-M Zhang
    H Lei
    L-H Zhu
    X-D Zhang
    D-P Liu
    H Li
    Cell Death & Differentiation, 2014, 21 : 888 - 903
  • [42] Regulatory effects of IRF4 on immune cells in the tumor microenvironment
    Lu, Jing
    Liang, Taotao
    Li, Ping
    Yin, Qingsong
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [43] Lineage- and Stage-Specific Oncogenicity of IRF4
    Amanda, Stella
    Tan, Tze King
    Iida, Shinsuke
    Sanda, Takaomi
    EXPERIMENTAL HEMATOLOGY, 2022, 114 : 9 - 17
  • [44] IRF4 Expression in Blastic Plasmacytoid Dendritic Cell Neoplasms
    van Slambrouck, C. M.
    Hyjek, E.
    Gurbuxani, S.
    LABORATORY INVESTIGATION, 2013, 93 : 364A - 365A
  • [45] IRF4 Expression in Blastic Plasmacytoid Dendritic Cell Neoplasms
    van Slambrouck, C. M.
    Hyjek, E.
    Gurbuxani, S.
    MODERN PATHOLOGY, 2013, 26 : 364A - 365A
  • [46] The role of IRF4 in Th2 polarisation in the skin
    Polak, M. E.
    Ung, C. Y.
    Masapust, J.
    Freeman, T. C.
    Ardern-Jones, M. R.
    Healy, E.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 : S8 - S8
  • [47] IRF4 is a novel mediator for neuronal survival in ischaemic stroke
    Guo, S.
    Li, Z-Z
    Jiang, D-S
    Lu, Y. Y.
    Liu, Y.
    Gao, L.
    Zhang, S-M
    Lei, H.
    Zhu, L-H
    Zhang, X-D
    Liu, D-P
    Li, H.
    CELL DEATH AND DIFFERENTIATION, 2014, 21 (06): : 888 - 903
  • [48] The Immune Transcriptional Factor Irf4 is a Key Regulator of Thermogenesis
    Kong, Xingxing
    Banks, Alexander
    Liu, Tiemin
    Wang, Xun
    Kleiner, Sander
    Kang, Sona
    Rosen, Evan D.
    CIRCULATION, 2013, 128 (22)
  • [49] Molecular interactions of IRF4 in B cell development and malignancies
    Sundararaj, Srinivasan
    Casarotto, Marco G.
    BIOPHYSICAL REVIEWS, 2021, 13 (06) : 1219 - 1227
  • [50] LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT
    Plastinina, L., V
    Moiseeva, T. N.
    Al-Radi, L. S.
    Kovrigina, A. M.
    Obukhova, T. N.
    Goryacheva, S. R.
    Shupletsova, I. A.
    Magomedova, A. U.
    Kravchenko, S. K.
    GEMATOLOGIYA I TRANSFUZIOLOGIYA, 2021, 66 (03): : 445 - 457
12345