Targeting IRF4 in autoimmune diseases

被引：72
|
作者：
Xu, Wang-Dong [1 ]
Pan, Hai-Feng [1 ]
Ye, Dong-Qing [1 ]
Xu, Yuekang [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China
[2] Univ Melbourne, Inst Bio21, Dept Biochem & Mol Biol, Melbourne, Vic 3010, Australia
来源：
AUTOIMMUNITY REVIEWS | 2012年 / 11卷 / 12期
基金：
英国医学研究理事会; 中国国家自然科学基金;
关键词：
Interferon regulatory factor 4; Immune cells; Immune response; Autoimmune diseases; INTERFERON-REGULATORY FACTOR-4; PLASMA-CELL DIFFERENTIATION; TRANSCRIPTION FACTOR IRF4; CD4(+) T-CELLS; CENTER B-CELLS; LYMPHOCYTE DIFFERENTIATION; GENE-EXPRESSION; EXPERIMENTAL COLITIS; CYTOKINE PRODUCTION; DENDRITIC CELLS;
D O I：
10.1016/j.autrev.2012.08.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
As a member of the IRF family of transcription factors, interferon regulatory factor 4 (IRF4) is expressed in most cell types of the immune system. Recent findings suggest that IRF4 is essential for the development and function of T helper (Th) cell, regulatory T (Treg) cell, B cell, as well as dendritic cell (DC). Since these cells are crucial in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), and type I diabetes, the roles of IRF4 in the initiation and progression of autoimmune diseases can not be neglected. In this review, we summarize recent advances on the pathological roles of IRF4 in autoimmunity and discuss the therapeutic significance of these new findings. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：918 / 924
页数：7
相关论文
共 50 条
  • [21] IRF4 Shapes the Tumor Microenvironment of Follicular Lymphoma
    Mondello, Patrizia
    Wenzl, Kerstin
    Yang, Zhi-Zhang
    Hong, Changjin
    Krull, Jordan E.
    Tang, Xinyi
    Bhardwaj, Vaishali
    Novak, Joseph P.
    Kim, Hyojin
    Mukherjee, Prithviraj
    King, Rebecca L.
    Hwang, Tae Hyun
    Shlomchik, Mark J.
    Novak, Anne J.
    Ansell, Stephen M.
    BLOOD, 2022, 140
  • [22] The dynamic functions of IRF4 in B cell malignancies
    Maffei, Rossana
    Fiorcari, Stefania
    Atene, Claudio Giacinto
    Martinelli, Silvia
    Mesini, Nicolo
    Pilato, Flora
    Lagreca, Ivana
    Barozzi, Patrizia
    Riva, Giovanni
    Nasillo, Vincenzo
    Paolini, Ambra
    Forghieri, Fabio
    Potenza, Leonardo
    Trenti, Tommaso
    Tagliafico, Enrico
    Luppi, Mario
    Marasca, Roberto
    CLINICAL AND EXPERIMENTAL MEDICINE, 2023, 23 (04) : 1171 - 1180
  • [23] Human inborn errors of immunity associated with IRF4
    Thouenon, Romane
    Kracker, Sven
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [24] IRF4: COMMON REGULATORY ROLE IN CHILDHOOD LEUKEMIA?
    Adamaki, M.
    Lambrou, G.
    Athanasiadou, A.
    Divane, A.
    Tzanoudaki, M.
    Vlahopoulos, S.
    Moschovi, M.
    PEDIATRIC BLOOD & CANCER, 2013, 60 : 221 - 221
  • [25] A decisive role of IRF4 for Tfh cell development
    Bollig, N.
    Bruestle, A.
    Kellner, K.
    Brendel, C.
    Huber, M.
    Kroczek, R. A.
    Dong, C.
    Jacob, R.
    Mak, T. W.
    Lohoff, M.
    IMMUNOLOGY, 2012, 137 : 7 - 7
  • [26] Critical Functions of IRF4 in B and T Lymphocytes
    Hagman, James
    JOURNAL OF IMMUNOLOGY, 2017, 199 (11): : 3715 - 3716
  • [27] Super-enhancer analysis defines IRF4 as a target in anaplastic large cell lymphoma and rational design of IRF4 degrader molecules
    Giordano, C.
    Prutsch, N.
    Gurnhofer, E.
    Aplenc, A.
    Kenner, L.
    Look, A. T.
    Touaibia, M.
    Merkel, O.
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 264 - 264
  • [28] IRF4 haploinsufficiency in a family with Whipple's disease
    Guerin, Antoine
    Kerner, Gaspard
    Marr, Nico
    Markle, Janet G.
    Fenollar, Florence
    Wong, Natalie
    Boughorbel, Sabri
    Avery, Danielle T.
    Ma, Cindy S.
    Bougarn, Salim
    Bouaziz, Matthieu
    Beziat, Vivien
    Della Mina, Erika
    Oleaga-Quintas, Carmen
    Lazarov, Tomi
    Worley, Lisa
    Tina Nguyen
    Patin, Etienne
    Deswarte, Caroline
    Martinez-Barricarte, Ruben
    Boucherit, Soraya
    Ayral, Xavier
    Edouard, Sophie
    Boisson-Dupuis, Stephanie
    Rattina, Vimel
    Bigio, Benedetta
    Vogt, Guillaume
    Geissmann, Frederic
    Quintana-Murci, Lluis
    Chaussabel, Damien
    Tangye, Stuart G.
    Raoult, Didier
    Abel, Laurent
    Bustamante, Jacinta
    Casanova, Jean-Laurent
    ELIFE, 2018, 7
  • [29] The dynamic functions of IRF4 in B cell malignancies
    Rossana Maffei
    Stefania Fiorcari
    Claudio Giacinto Atene
    Silvia Martinelli
    Nicolò Mesini
    Flora Pilato
    Ivana Lagreca
    Patrizia Barozzi
    Giovanni Riva
    Vincenzo Nasillo
    Ambra Paolini
    Fabio Forghieri
    Leonardo Potenza
    Tommaso Trenti
    Enrico Tagliafico
    Mario Luppi
    Roberto Marasca
    Clinical and Experimental Medicine, 2023, 23 : 1171 - 1180
  • [30] Heterogenous Role of IRF4 in Kidney Fibrosis Reply
    Harris, Raymond C.
    Zhang, Ming-Zhi
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (11): : 2972 - 2972
12345