Stimulation of TNF-α release by fungal cell wall polysaccharides

被引:0
作者
Majtán, J
Kogan, G
Kovácová, E
Bíliková, K
Simúth, J
机构
[1] Slovak Acad Sci, Inst Chem, Ctr Excellence CEDEBIPO, Bratislava 84538, Slovakia
[2] Slovak Acad Sci, Inst Mol Biol, Bratislava 84551, Slovakia
[3] Slovak Acad Sci, Inst Virol, Bratislava 84245, Slovakia
[4] Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany
来源
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2005年 / 60卷 / 11-12期
关键词
tumor necrosis factor-alpha; glucan; chitin;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Carboxymethylated derivatives were prepared from the (1 -> 3)-beta-D-glucan isolated from the cell wall of baker's yeast Saccharomyces cerevisiae and from the chitin-glucan complex of the mycelium of the industrial filamentous fungus Aspergillus niger. The polysaccharides were applied to peritoneal mouse macrophages and after a 2-h incubation the release of TNF-alpha by the stimulated macrophages was measured using an enzyme-linked immunosorbent assay. As the third polysaccharide stimulant, a water-soluble derivative of chitin was assayed and the observed cytokine release was compared with the control experiment. In three concentrations of the polysaccharides applied, carboxymethyl glucan revealed a dramatic increase in the TNF-a release, while addition of carboxymethyl chitin-glucan resulted only in a moderate enhancement, and carboxymethyl chitin was inactive. The results indicate that fungal polysaccharides, especially (1 -> 3)-beta-D-glucan, are potent macrophage stimulators and activators of TNF-a release, which implies their potential application in antitumor therapy.
引用
收藏
页码:921 / 926
页数:6
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