Substituted morpholine-2S-acetic acid derivatives: Sch 50911 and related compounds as novel GABA(B) antagonists

被引：19

作者：

Blythin, DJ ^{[1
]}

Kuo, SC ^{[1
]}

Shue, HJ ^{[1
]}

McPhail, AT ^{[1
]}

Chapman, RW ^{[1
]}

Kreutner, W ^{[1
]}

Rizzo, C ^{[1
]}

She, HS ^{[1
]}

West, R ^{[1
]}

机构：

[1] DUKE UNIV,PAUL M GROSS CHEM LAB,DURHAM,NC 27708

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(96)00267-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and GABA(B) antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X-ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1529 / 1534

页数：6

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