Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea

被引：16
|
作者：
Monte, Leonardo G. [1 ]
Jorge, Sergio [2 ]
Xavier, Marina A. [1 ]
Leal, Fernanda M. A. [1 ]
Amaral, Marta G. [1 ]
Seixas, Fabiana K. [3 ]
Dellagostin, Odir A. [2 ]
Hartleben, Claudia P. [1 ]
机构：
[1] Univ Fed Pelotas, Lab Imunodiagnost, Nucleo Biotecnol, Ctr Desenvolvimento Tecnol, BR-96010900 Pelotas, RS, Brazil
[2] Univ Fed Pelotas, Lab Vacinol, BR-96010900 Pelotas, RS, Brazil
[3] Univ Fed Pelotas, Lab Genom Func, BR-96010900 Pelotas, RS, Brazil
来源：
ACTA TROPICA | 2013年 / 126卷 / 02期
关键词：
Leptospirosis; Brazilian guinea pig; Wild rodent; IDENTIFICATION; BORRELIA;
D O I：
10.1016/j.actatropica.2013.02.009
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Leptospirosis is a worldwide zoonotic infection caused by pathogenic Leptospira. Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia aperea (Brazilian guinea pig). The isolated strain was characterized by partial rpoB gene sequencing, variable-number tandem-repeats and histopathological analysis. The strain was identified as Leptospira interrogans, serogroup Icterohaemorrhagiae and caused clinical signs of leptospirosis in the hamster model, attesting to its virulence. In conclusion, these findings could be useful for elucidating the epidemiological role of C aperea in leptospirosis. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：164 / 166
页数：3
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