Synthetic biology in cell-based cancer immunotherapy

被引：54

作者：

Chakravarti, Deboki ^{[1
]}

Wong, Wilson W. ^{[1
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2015年 / 33卷 / 08期

关键词：

CHIMERIC-ANTIGEN-RECEPTOR; MODIFIED T-CELLS; ZINC-FINGER; STEM-CELLS; GENETIC-MODIFICATION; ANTITUMOR-ACTIVITY; EFFECTOR FUNCTION; NEO-ANTIGENS; TUMOR; GENOME;

D O I：

10.1016/j.tibtech.2015.05.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The adoptive transfer of genetically engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. This form of cellular immunotherapy presents a unique opportunity to incorporate advanced systems and synthetic biology approaches to create cancer therapeutics with novel functions. We first review the development of synthetic receptors, switches, and circuits to control the location, duration, and strength of T cell activity against tumors. In addition, we discuss the cellular engineering and genome editing of host cells (or the chassis) to improve the efficacy of cell-based cancer therapeutics, and to reduce the time and cost of manufacturing.

引用

页码：449 / 461

页数：13

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