Role of Bile Acids in Metabolic Control

被引：396

作者：

Molinaro, Antonio ^{[1
]}

Wahlstrom, Annika ^{[1
]}

Marschall, Hanns-Ulrich ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 01期

关键词：

FARNESOID X-RECEPTOR; FATTY LIVER-DISEASE; Y GASTRIC BYPASS; IMPROVES GLUCOSE-HOMEOSTASIS; OBETICHOLIC ACID; LIPID-METABOLISM; GUT MICROBIOTA; NONALCOHOLIC STEATOHEPATITIS; URSODEOXYCHOLIC ACID; INSULIN SENSITIVITY;

D O I：

10.1016/j.tem.2017.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble nutrients regulate numerous metabolic processes, including glucose, lipid, and energy homeostasis. The signaling actions of bile acids are mediated through specific bile-acid-activated nuclear and membrane-bound receptors. These receptors are not only expressed by tissues within the enterohepatic circulation such as the liver and the intestine, but also in other organs where bile acids mediate their systemic actions. In this review, we discuss bile acid signaling and the interplay with the gut microbiota in the pathophysiology of obesity, type 2 diabetes, and non-alcoholic fatty liver disease, and the role of surgical and pharmacological interventions on bile acid profiles and metabolism.

引用

页码：31 / 41

页数：11

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