Obesity prolongs the hospital stay in patients affected by COVID-19, and may impact on SARS-COV-2 shedding

被引:86
作者
Moriconi, Diego [1 ]
Masi, Stefano [1 ]
Rebelos, Eleni [1 ]
Virdis, Agostino [1 ]
Manca, Maria Laura [1 ]
De Marco, Salvatore [2 ]
Taddei, Stefano [1 ]
Nannipieri, Monica [1 ]
机构
[1] Univ Pisa, Dept Clin & Expt Med, Via Savi 10, I-56126 Pisa, Italy
[2] Azienda Osped Univ Pisa, AOUP, Pisa, Italy
关键词
Obesity; COVID-19; Citokynes; CRP; Viral shedding; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; RISK; ASSOCIATION; WEIGHT;
D O I
10.1016/j.orcp.2020.05.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: On the last three months the new SARS-COV-2 coronavirus has created a pandemic, rapidly spreading all around the world. The aim of the study is to investigate whether obesity impacts on COVID19 morbidity. Methods: One hundred consecutive patients with COVID-19 pneumonia admitted in our Medical Unit were evaluated. Anthropometric parameters and past medical history were registered. Nasopharyngeal swab samples and biochemical analysis were obtained at admission and during hospital stay. Results: Patients with (OB, 29) and without obesity (N-OB, 71) were similar in age, gender and comorbidities, with the exception of hypertension that was more frequent in OB group. At admission, inflammatory markers were higher in OB than N-OB group. OB group showed a worse pulmonary clinical picture, with lower PaO2 (57 +/- 15 vs. 68 +/- 14 mmHg, p = 0.042), and SaO2 (88 +/- 6 vs. 92 +/- 5%, p = 0.049) at admission consequently requiring higher volumes of oxygen (FiO2: 38 +/- 15 vs. 29 +/- 19%, p = 0.047) and a longer period to achieve oxygen weaning (10 +/- 6 vs. 15 +/- 7 days, p = 0.03). OB group also had positive swabs for longer time (19 +/- 8 vs. 13 +/- 7, days, p = 0.002), and required longer hospital stay (21 +/- 8 vs. 13 +/- 8, days, p = 0.0008). Partial least square regression analysis showed that BMI, age and CRP at admission were related to longer length of hospital stay, and time for negative swab. On the contrary, in this cohort, obesity did not predict higher mortality. Conclusions: Subjects with obesity affected by COVID-19 require longer hospitalization, more intensive and longer oxygen treatment, and they may have longer SARS-COV-2 shedding. (c) 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:205 / 209
页数:5
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