HIV-1 RNA shedding in the female genital tract is associated with reduced quantity of Lactobacilli in clinically asymptomatic HIV-positive women

被引：6

作者：

Mane, Arati ^{[1
]}

Kulkarni, Smita ^{[1
]}

Ghate, Manisha ^{[1
]}

Risbud, Arun ^{[1
]}

Thakar, Madhuri ^{[1
]}

机构：

[1] Natl AIDS Res Inst, MIDC, Pune 411026, Maharashtra, India

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2013年 / 75卷 / 01期

关键词：

HIV-1; Genital shedding; Lactobacilli; IMMUNODEFICIENCY-VIRUS TYPE-1; BACTERIAL VAGINOSIS;

D O I：

10.1016/j.diagmicrobio.2012.09.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We quantified vaginal lactobacilli and determined their relationship with genital HIV-1 shedding and found a significant negative association between reduced quantity of lactobacilli and cervical HIV-1 viral load (r(2) = - 0.8900, P < 0.01), which may have implications of increased chances of sexual transmission of HIV-1 and genital infections. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：112 / 114

页数：3

共 39 条

[1] Characterization of vaginal lactobacilli from HIV-negative and HIV-positive Indian women and their association with genital HIV-1 shedding
Mane, Arati
Angadi, Mansa
Vidhate, Pallavi
Bembalkar, Shilpa
Khan, Ishrat
Bichare, Shubhangi
Ghate, Manisha
Thakar, Madhuri
JOURNAL OF MEDICAL MICROBIOLOGY, 2017, 66 (10) : 1471 - 1475
[2] Shedding of HIV-1 in the genital tract
Mostad, SB
Kreiss, JK
AIDS, 1996, 10 (12) : 1305 - 1315
[3] Correlates of HIV-1 Genital Shedding in Tanzanian Women
Tanton, Clare
Weiss, Helen A.
Le Goff, Jerome
Changalucha, John
Rusizoka, Mary
Baisley, Kathy
Everett, Dean
Ross, David A.
Belec, Laurent
Hayes, Richard J.
Watson-Jones, Deborah
PLOS ONE, 2011, 6 (03):
[4] The effect of hormonal contraception on genital tract shedding of HIV-1
Wang, CC
McClelland, RS
Overbaugh, J
Reilly, M
Panteleeff, DD
Mandaliya, K
Chohan, B
Lavreys, L
Ndinya-Achola, J
Kreissa, JK
AIDS, 2004, 18 (02) : 205 - 209
[5] Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women
Nagot, N
Foulongne, V
Becquart, P
Mayaud, P
Konate, I
Ouedraogo, A
Defer, MC
Weiss, H
Van de Perre, P
Segondy, M
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2005, 39 (05) : 632 - 634
[6] Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3
Chung, Michael H.
McKenzie, Kevin P.
Richardson, Barbra A.
John-Stewart, Grace C.
Coombs, Robert W.
De Vuyst, Hugo
Njoroge, Julia W.
Nyongesa-Malava, Evans
Sakr, Samah R.
Mugo, Nelly R.
AIDS, 2011, 25 (15) : 1915 - 1919
[7] Infectious correlates of HIV-1 shedding in the female upper and lower genital tracts
Coleman, Jenell S.
Hitti, Jane
Bukusi, Elizabeth A.
Mwachari, Christina
Muliro, Angela
Nguti, Rosemary
Gausman, Reggie
Jensen, Sarah
Patton, Dorothy
Lockhart, David
Coombs, Robert
Cohen, Craig R.
AIDS, 2007, 21 (06) : 755 - 759
[8] Selenium deficiency is associated with shedding of HIV-1-infected cells in the female genital tract
Baeten, JM
Mostad, SB
Hughes, MP
Overbaugh, J
Bankson, DD
Mandaliya, K
Ndinya-Achola, JO
Bwayo, JJ
Kreiss, JK
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2001, 26 (04) : 360 - 364
[9] Micronutrient supplementation increases genital tract shedding of HIV-1 in women - Results of a randomized trial
McClelland, RS
Baeten, JM
Overbaugh, J
Richardson, BA
Mandaliya, K
Emery, S
Lavreys, L
Ndinya-Achola, JO
Bankson, DD
Bwayo, JJ
Kreiss, JK
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2004, 37 (05) : 1657 - 1663
[10] Reduced quantity and hydrogen-peroxide production of vaginal lactobacilli in HIV positive women
Knezevic, A
Stepanovic, S
Cupic, M
Jevtovic, D
Ranin, J
Jovanovic, T
BIOMEDICINE & PHARMACOTHERAPY, 2005, 59 (09) : 521 - 523

← 1 2 3 4 →