Atherosclerosis: lessons from LXR and the intestine

被引：58

作者：

Bonamassa, Barbara ^{[1
]}

Moschetta, Antonio ^{[1
,2
,3
,4
]}

机构：

[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Translat Pharmacol, Lab Lipid Metab & Canc, I-66030 Santa Maria Imbaro, CH, Italy

[2] Univ Bari, Dept Med, Clin Med A Murri, I-70124 Bari, Italy

[3] Natl Canc Inst Giovanni Paolo II, Bari, Italy

[4] Ist Ricovero & Cura Carattere Sci IRCCS S de Bell, Natl Inst Digest Dis, Bari, Italy

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 03期

关键词：

atherosclerosis; liver X receptors (LXRs); intestine; high-density lipoprotein (HDL); reverse cholesterol transport (RCT); REVERSE CHOLESTEROL TRANSPORT; BINDING CASSETTE TRANSPORTER; DENSITY-LIPOPROTEIN CHOLESTEROL; X RECEPTOR AGONIST; BILIARY STEROL SECRETION; NIEMANN-PICK C1-LIKE-1; PLASMA HDL CHOLESTEROL; APOLIPOPROTEIN-A-I; DIET-INDUCED HYPERCHOLESTEROLEMIA; ACYL-COENZYME;

D O I：

10.1016/j.tem.2012.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Modulation of the cholesterol-sensing liver X receptors (LXRs) and their downstream targets has emerged as promising therapeutic avenues in atherosclerosis. The intestine is important for its unique capabilities to act as a gatekeeper for cholesterol absorption and to participate in the process of cholesterol elimination in the feces and reverse cholesterol transport (RCT). Pharmacological and genetic intestine-specific LXR activation have been shown to protect against atherosclerosis. In this review we discuss the LXR-targeted molecular players in the enterocytes as well as the intestine-driven pathways contributing to cholesterol homeostasis with therapeutic potential as targets in the prevention and treatment of atherosclerosis..

引用

页码：120 / 128

页数：9

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