MicroRNAs as mediators of viral evasion of the immune system

被引：190

作者：

Cullen, Bryan R. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27708 USA

[2] Duke Univ, Med Ctr, Ctr Virol, Durham, NC USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TRANSLATION INITIATION; HERPESVIRUS MICRORNA; POSTTRANSCRIPTIONAL REGULATION; GENE-EXPRESSION; VIRUS MICRORNA; MESSENGER-RNA; TARGET; MIR-155; RECOGNITION; LATENT;

D O I：

10.1038/ni.2537

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cellular microRNAs serve key roles in the post-transcriptional regulation of almost every cellular gene-regulatory pathway, and it therefore is not surprising that viruses have found ways to subvert this process. Several viruses encode microRNAs that directly downregulate the expression of factors of the innate immune system, including proteins involved in promoting apoptosis and recruiting effector cells of the immune system. Viruses have also evolved the ability to downregulate or upregulate the expression of specific cellular miRNAs to enhance their replication. This Review provides an overview of the present knowledge of the complex interactions of viruses with the microRNA machinery of cells.

引用

页码：205 / 210

页数：6

共 89 条

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