Dietary treatment of nonalcoholic steatohepatitis

被引：16
作者：
Perito, Emily R. [1 ]
Rodriguez, Luis A. [2 ]
Lustig, Robert H. [1 ,3 ]
机构：
[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA
[2] Univ Calif San Francisco, UCSF Med Ctr, Dept Nutr & Food Serv, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA
来源：
CURRENT OPINION IN GASTROENTEROLOGY | 2013年 / 29卷 / 02期
关键词：
fructose; lipotoxicity; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; trans-fat; FATTY LIVER-DISEASE; LIFE-STYLE INTERVENTION; ALANINE AMINOTRANSFERASE LEVELS; DE-NOVO LIPOGENESIS; HIGH-FRUCTOSE; SWEETENED BEVERAGES; HEPATIC STEATOSIS; INSULIN SENSITIVITY; GENETIC-VARIATION; OBESE CHILDREN;
D O I：
10.1097/MOG.0b013e32835ca11d
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Purpose of review Nonalcoholic steatohepatitis (NASH) is increasing in prevalence, in tandem with the U. S. obesity epidemic, in both children and adults. Identifying specific dietary components that drive NASH is important for successful management of this disease. Recent findings Weight loss of 5-10% improves NASH. In addition, fructose and trans-fats, two components of the Western 'fast-food' diet, have unique metabolic effects that suggest they may be key contributors to NASH. However, further research is needed to clarify the utility of restricting these nutrients in treating NASH. Summary Overall reductions in body weight, through reduced calorie intake and increased physical activity, are the current mainstays of NASH treatment. Reducing fructose and trans-fat intake, independent of weight loss, may be critical to improving or preventing progression of NASH.
引用
收藏
页码：170 / 176
页数：7
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