Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

被引:18
作者
Wang, Yitong [1 ,2 ,3 ,4 ,5 ]
Chen, Hui [1 ]
Lin, Kaili [2 ,3 ,4 ,5 ]
Ying, Ting [6 ]
Huang, Quan [7 ]
Cai, Xiaopan [7 ]
Xiao, Jianru [7 ]
Zhang, Qiang [1 ]
Cheng, Yiyun [1 ,8 ]
机构
[1] East China Normal Univ, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Sch Med,Dept Oral & Craniomaxillofacial Surg, Shanghai 200011, Peoples R China
[3] Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China
[4] Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
[5] Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China
[6] Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai 200234, Peoples R China
[7] Second Mil Med Univ, Changzheng Hosp, Dept Orthoped Oncol, Shanghai 200003, Peoples R China
[8] South China Univ Technol, Sch Mol Sci & Engn, South China Adv Inst Soft Matter Sci & Technol, Guangzhou 510640, Peoples R China
基金
中国国家自然科学基金;
关键词
targeted nanoparticles; cancer therapy; multifunctional nanoparticles; drug delivery; bone targeting; SKELETAL-RELATED EVENTS; PROSTATE-CANCER; OSTEOCLAST DIFFERENTIATION; PHOTOTHERMAL THERAPY; GOLD NANOCAGES; LUNG-CANCER; IN-VITRO; METASTASIS; MICROENVIRONMENT; AUTOPHAGY;
D O I
10.1007/s40843-020-1405-8
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors. Here, we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine (CQ)-loaded polydopamine nanoparticles (PPA/CQ) for efficient treatment of bone tumorsviabreaking the vicious cycle. The nanoparticles were efficiently accumulated to the bone tissues, especially the osteolytic lesions around tumors. CQ released from PPA/CQ inhibited osteoclastogenesisviapreventing the degradation of tumor necrosis factor (TNF) receptor-associated receptor 3 to attenuate the osteolysis in bone tumors. On the other hand, CQ blocked the autophagy in cancer cells, resulting in improved photothermal killing of cancer cells. Finally, thein vivoexperiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and osteolysis. This work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.
引用
收藏
页码:474 / 487
页数:14
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