New jatrophane diterpenes from Euphorbia osyridea with proapoptotic effects on ovarian cancer cells

被引：16

作者：

Ghanadian, Mustafa ^{[1
]}

Saeidi, Hojjatollah ^{[2
]}

Aghaei, Mahmoud ^{[3
]}

Rahiminejad, Mohammad Reza

Ahmadi, Elham ^{[2
]}

Ayatollahi, Syed Majid ^{[4
]}

Choudhary, M. Iqbal ^{[5
,6
]}

Bahmani, Behzad ^{[3
]}

机构：

[1] Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Esfahan, Iran

[2] Univ Isfahan, Fac Sci, Dept Biol, Esfahan, Iran

[3] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Esfahan, Iran

[4] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran

[5] Univ Karachi, ICCBS, HEJ Res Inst Chem, Karachi 75270, Pakistan

[6] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah 214421, Saudi Arabia

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 12卷

关键词：

Euphorbia osyridea; Euphorbiaceae; Caov-4 and OVCAR-3 cancer cell lines; Cytotoxic activity; Jatrophane diterpenes; MACROCYCLIC DITERPENOIDS; LATERIFLORA; AGENTS;

D O I：

10.1016/j.phytol.2015.04.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A dichloromethane-acetone extract of Euphorbia osyridea Bioss. (Syn. Euphorbia lateriflora Schumach. & Thonn), a spurge endemic to Iran and West Africa, afforded three new jatrophane diterpenes belonging to the 2,3,5,7,8,9,14,15-octahydroxy-jatropha-6(17), 11E-diene class along with three known triterpenes. Structures of these compounds were elucidated by spectroscopic methods, especially 2D NMR analyses. Biological effects of these compounds were analyzed by performing MTT and annexin V-FITC and PI staining assays against different cancer cell lines. Results showed that 2,3,5,7,8,9,14,15-octahydroxy-jatropha-6(17), 11E-diene derivatives (1-3) inhibit the cell proliferation through apoptosis in the Caov-4 and OVCAR-3 cancer cell lines. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：302 / 307

页数：6

共 18 条

[1] Inhibition of tumor cells growth and stimulation of lymphocytes by Euphorbia species [J].

Amirghofran, Zahra ;

Malek-hosseini, Saeed ;

Gholmoghaddam, Hossein ;

Kalalinia, Fatemeh .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2011, 33 (01) :34-42

[2] Macrocyclic diterpenoids from Euphorbia semiperfoliata [J].

Appendino, G ;

Jakupovic, S ;

Tron, GC ;

Jakupovic, J ;

Milon, V ;

Ballero, M .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06) :749-756

[3] Macrocyclic diterpenoids from Euphorbia hyberna L. subsp insularis and their reaction with oxyphilic reagents [J].

Appendino, G ;

Spagliardi, P ;

Ballero, M ;

Seu, G .

FITOTERAPIA, 2002, 73 (7-8) :576-582

[4] New myrsinane-type diterpenoids from Euphorbia aellenii Rech. f. with their immunomodulatory activity [J].

Ayatollahi, Abdul Majid ;

Ghanadian, Mustafa ;

Mesaik, M. Ahmed ;

Abdella, Omer Mohamed ;

Afsharypuor, Suleiman ;

Kobarfard, Farzad ;

Mirza-taheri, Marjan .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2010, 12 (12) :1020-1025

[5] Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy [J].

Corea, G. ;

Di Pietro, A. ;

Dumontet, C. ;

Fattorusso, E. ;

Lanzotti, V. .

PHYTOCHEMISTRY REVIEWS, 2009, 8 (02) :431-447

[6] Plants as a source of anti-cancer agents [J].

Cragg, GM ;

Newman, DJ .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 100 (1-2) :72-79

[7] THE STRUCTURE OF ENUKOKURIN, A NEW JATROPHANE DITERPENOID FROM THE LATEX OF EUPHORBIA-LATERIFLORA [J].

FAKUNLE, CO ;

CONNOLLY, JD ;

RYCROFT, DS .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (02) :279-283

[8] Jatrophane and lathyrane diterpenoids from Euphorbia hyberna L. [J].

Ferreira, AMVD ;

Carvalho, LHM ;

Carvalho, MJM ;

Sequeira, MM ;

Silva, AMS .

PHYTOCHEMISTRY, 2002, 61 (04) :373-377

[9] New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis [J].

Ghanadian, Syed Mustafa ;

Ayatollahi, Abdul Majid ;

Afsharypuor, Suleiman ;

Javanmard, Shaghayegh Haghjooy ;

Dana, Nasim .

JOURNAL OF NATURAL MEDICINES, 2013, 67 (02) :327-332

[10] New immunosuppressive cyclomyrsinol diterpenes from Euphorbia kopetdaghi Prokh [J].

Ghanadian, Syed Mustafa ;

Ayatollahi, Abdul Majid ;

Mesaik, M. Ahmed ;

Abdalla, Omer Mohamed .

NATURAL PRODUCT RESEARCH, 2013, 27 (03) :246-254

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