Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*]+X- for X = BF4-, PF6-, and BPh4-

被引：59

作者：

Loughrey, Bradley T. ^{[1
]}

Healy, Peter C. ^{[1
]}

Parsons, Peter G. ^{[2
]}

Williams, Michael L. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Brisbane, Qld 4111, Australia

[2] Queensland Inst Med Res, Drug Discovery Grp, Brisbane, Qld 4006, Australia

来源：

INORGANIC CHEMISTRY | 2008年 / 47卷 / 19期

关键词：

D O I：

10.1021/ic801159f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel series of ionic Ru(II) arene Cp* sandwich complexes has been synthesized and characterized. Screening results for cytotoxicity against a range of human tumor cell lines and normal human cells indicate that the complexes show promising anticancer activity, which varies with changes in the arene ligand and the anionic counterion.

引用

页码：8589 / 8591

页数：3

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